Effects of overweight and obesity on standardized treatment and pulmonary function in children with bronchial asthma
LI Jingpeng1 LIU Chuanhe2▲ WANG Mengmeng1 WEI Hong1 WANG Genxiang1
1.Department of Pediatrics, Zhanlanlu Hospital in Xicheng District, Beijing 100044, China;
2.Department of Asthma Center and Lung Function Laboratory, Children’s Hospital, Capital Institute of Pediatrics, Beijing 100020, China
Abstract：Objective To investigate the effects of overweight and obesity on standardized treatment and pulmonary function in children with bronchial asthma (“asthma” for short). Methods A total of 120 children with acute asthma attack from January 2020 to January 2021 in the Department of Pediatric Outpatient, Zhanlanlu Hospital in Xicheng District, Beijing were selected as the research objects. According to the body mass index percentile numerical method, they were divided into overweight and obesity group (≥85%, 59 cases) and normal weight group (16%-＜85%, 61 cases). Both groups received standardized treatment, the clinical efficacy of two groups was compared; the number of asthma attacks, emergency department visits due to asthma attacks, and lung function level were compared between two groups. Results The number of annual attacks and emergency department visits due to asthma attacks in overweight and obesity group was higher than those in normal weight group, and the score of asthma control test was lower than that in normal weight group, and the differences were statistically significant (P＜0.05). The clinical effect of overweight and obesity group was worse than that of normal weight group, and the difference was statistically significant (P＜0.05). After treatment, forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in one second (FEV1), FEV1/FVC, and forced expiratory flow at 50% forced vital capacity (FEF50) in normal weight group were higher than those before treatment; FVC, PEF, FEV1, and FEV1/FVC in overweight and obese group were higher than those before treatment, and the differences were statistically significant (P＜0.05). There was no significant difference in FEF50 between overweight and obese groups before and after treatment (P＞0.05). The improvement rates of FEV1, FEV1/FVC, PEF, and FEF50 in overweight and obese groups were lower than those in normal weight group, and the differences were statistically significant (P＜0.05). Conclusion Overweight and obesity in children are associated with poor asthma control and can increase lung function impairment in children with asthma.
李京鹏1 刘传合2▲ 王蒙蒙1 魏红1 王根香1. 超重及肥胖对支气管哮喘儿童规范化治疗效果及肺功能的影响[J]. 中国医药导报, 2023, 20(6): 108-111.
LI Jingpeng1 LIU Chuanhe2▲ WANG Mengmeng1 WEI Hong1 WANG Genxiang1. Effects of overweight and obesity on standardized treatment and pulmonary function in children with bronchial asthma. 中国医药导报, 2023, 20(6): 108-111.
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