外周血系统免疫炎症指数联合24 h尿蛋白定量对早发型重度子痫前期不良妊娠结局的预测价值

doi:10.20047/j.issn1673-7210.2023.35.25

摘要
图/表
参考文献
相关文章 (5)

全文: PDF (544 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨早发型重度子痫前期（EOSP）患者外周血系统免疫炎症指数（SII）、24 h尿蛋白定量对不良妊娠结局的预测价值。方法选取2021年6月至2022年12月河北省沧州市人民医院EOSP伴不良分娩结局孕妇65例，作为不良结局组；另收集同期EOSP且结局良好孕妇65例作为良好结局组。收集并比较两组临床资料；分析EOSP不良妊娠结局的影响因素及SII、24 h尿蛋白定量对EOSP不良妊娠结局的预测价值。结果不良结局组白细胞计数、24 h尿蛋白定量、中性粒细胞计数、SII高于良好结局组，淋巴细胞计数低于良好结局组，差异有统计学意义（P＜0.05）。SII、24 h尿蛋白定量是EOSP患者不良妊娠结局的危险因素（OR＞1，P＜0.05）。SII、24 h尿蛋白定量与EOSP患者不良妊娠结局呈正相关（r=0.301，0.479，P＜0.05）。外周血SII联合24 h尿蛋白定量预测EOSP不良妊娠结局的曲线下面积高于各指标单独预测（P＜0.05）。结论外周血SII及24 h尿蛋白定量异常升高是EOSP患者不良妊娠结局发生的独立危险因素，且具有一定的预测价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	门贺伟　　刘　倩　　李　霞　　谢晓梅　　王丽丽

关键词 ：早发型重度子痫前期, 系统免疫炎症指数, 24 h尿蛋白定量, 不良妊娠结局

Abstract：Objective To investigate the predictive value of peripheral blood systematic immune-inflammation index (SII) combined with 24 h urinary protein quantification for adverse pregnancy outcome of early-onset severe preeclampsia (EOSP). Methods A total of 65 EOSP pregnant women with adverse delivery outcomes who were admitted to Cangzhou People’s Hospital, Hebei Province from June 2021 to December 2022 were enrolled as adverse outcomes group; in addition, 65 EOSP pregnant women with good delivery outcomes during the same period were enrolled as good outcomes group. The clinical data of two groups were collected; the influencing factors of EOSP adverse pregnancy outcome and the predictive value of SII and 24 h urinary protein inflammation quantification on EOSP adverse pregnancy outcome were analyzed. Results White blood cell count, 24 h urinary protein quantification, neutrophil count, and SII in adverse outcome group were higher than those in good outcome group, and lymphocyte count was lower than that in good outcome group, with statistical significances (P＜0.05). SII and 24 h urinary protein quantification were risk factors for adverse pregnancy outcomes in patients with EOSP (OR＞1, P＜0.05). SII and 24 h urinary protein quantification were positively correlated with adverse pregnancy outcomes in EOSP patients (r=0.301, 0.479, P＜0.05). The area under the curve of peripheral blood SII combined with 24 h urinary protein quantification prediction of EOSP adverse pregnancy outcome was higher than that of each index alone (P＜0.05). Conclusion Abnormal peripheral blood SII and 24 h urinary protein quantification are independent risk factors for adverse pregnancy outcomes in patients with EOSP, and have certain predictive value.

Key words： Early onset severe pre-eclampsia Systematic immune-inflammation index 24 h urinary protein quantification Adverse pregnancy outcome

基金资助:河北省医学科学研究课题计划项目（20210432）。

引用本文:

门贺伟　　刘　倩　　李　霞　　谢晓梅　　王丽丽. 外周血系统免疫炎症指数联合24 h尿蛋白定量对早发型重度子痫前期不良妊娠结局的预测价值[J]. 中国医药导报, 2023, 20(35): 115-118.
MEN Hewei LIU Qian LI Xia XIE Xiaomei WANG Lili. Predictive value of peripheral blood systematic immune-inflammation index combined with 24 h urinary protein quantification for adverse pregnancy outcome of early-onset severe preeclampsia. 中国医药导报, 2023, 20(35): 115-118.

链接本文:

https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.35.25 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I35/115