Abstract：Objective To investigate the clinical effect of Fupi Yishen Decoction in the treatment of moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney. Methods Sixty moderate and severe chronic periodontitis patients with syndrome of yang deficiency of spleen and kidney admitted to Wuhan Hospital of Traditional Chinese Medicine from April 2021 to May 2022 were selected as the study objects, and they were divided into control group (periodontal basic treatment) and observation group (periodontal basic treatment combined with Fupi Yishen Decoction) according to random number table method, with 30 cases in each group. The effects of the two groups were compared, and the differences of traditional Chinese medicine syndrome scores, periodontal indicators, and inflammatory factor indicators between the two groups were compared before treatment and one month after treatment, and the occurrence of adverse reactions during treatment between the two groups were recorded. Results The clinical efficacy of the observation group was better than that of the control group (P＜0.05). After one month of treatment, the scores of tooth loosening and displacement, gingival swelling, bleeding, and mastication weakness in two groups were lower than those before treatment, and those of observation group was lower than those of control group (P＜0.05). After one month of treatment, periodontal attachment level, plaque index, and periodontal pocket depth in two groups were lower than those before treatment, and those of observation group were lower than those of control group (P＜0.05). After one month of treatment, the gingival crevicular fluid tumor necrosis factor-α, interleukin-1β, interleukin-6, and serum C-reactive protein in two groups were lower than those before treatment, and those of observation group were lower than those of control group (P＜0.05). No obvious adverse reactions were observed in both groups during treatment. Conclusion Fupi Yishen Decoction adjuvant treatment of moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney, can promote the improvement of symptoms, and periodontal related indicators, reduce the level of inflammatory factors, the effect is significant.
俞梅 刘思佳 喻锦娴. 扶脾益肾汤辅助治疗脾肾阳虚型中重度慢性牙周炎的临床效果[J]. 中国医药导报, 2023, 20(30): 125-129.
YU Mei LIU Sijia YU Jinxian. Clinical effect of Fupi Yishen Decoction in treating moderate and severe chronic periodontitis with syndrome of yang deficiency of spleen and kidney. 中国医药导报, 2023, 20(30): 125-129.
2023, Vol. 20 
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