Systematic evaluation of serum vitamin D levels and efficacy of vitamin D supplementation in children with atopic dermatitis
CHEN Xi1 WANG Jianing1 SUN Dan2 YAN Xiaoning2 LI Wenbin2
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Dermatology, Shaanxi Provincial Hospital of Chinese Medicine, Shaanxi Province, Xi’an 710003, China
Abstract：Objective To determine serum 25-hydroxyvitamin D (25[OH]D) levels in children with atopic dermatitis (AD), and the effect of vitamin D supplementation on AD was evaluated by systematic analysis of vitamin D intervention. Methods The relevant literature on vitamin D and AD and vitamin D therapy for AD were searched by computer from PubMed, EMbase, CNKI, Wanfang Academic Journal Database, and VIP from January 2010 to November 2022. A meta-analysis method was used to systematically evaluate the retrieved literatures that met the inclusion criteria. Results Five randomized controlled trials (RCT) and 15 case-control studies were included. In RCT, eczema area and severity index in experimental group was higher than that in control group(WMD=-3.79, 95%CI[-6.38,-1.20], P=0.004); the scoring of atopic dermatitis in experimental group was higher than that in control group (WMD=-6.06, 95%CI[-10.12,-2.00], P=0.003). In the case- control study, serum 25(OH)D levels in AD children group were lower than that in control group (SMD=-0.80, 95%CI [-1.18,-0.41], P＜0.000 1). Conclusion Children with AD are at high risk of vitamin D deficiency, and vitamin D supplementation can improve clinical symptoms in children with AD.
陈曦1 王佳宁1 孙丹2 闫小宁2 李文彬2. 特应性皮炎患儿血清维生素D水平和补充维生素D疗效的系统评价[J]. 中国医药导报, 2023, 20(27): 108-112.
CHEN Xi1 WANG Jianing1 SUN Dan2 YAN Xiaoning2 LI Wenbin2. Systematic evaluation of serum vitamin D levels and efficacy of vitamin D supplementation in children with atopic dermatitis. 中国医药导报, 2023, 20(27): 108-112.
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