血清miR-125a-3p、miR-224-3p表达与脑梗死患者颈动脉粥样硬化斑块的关系

doi:10.20047/j.issn1673-7210.2023.26.19

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摘要目的探讨血清miR-125a-3p、miR-224-3p表达与脑梗死颈动脉粥样硬化（CAS）斑块的关系。方法选取2019年3月至2021年12月北京市和平里医院收治的120例脑梗死患者，根据CAS斑块稳定性将其分为不稳定组（75例）和稳定组（45例）。收集并比较两组临床资料，同时采用实时荧光定量PCR检测两组血清miR- 125a-3p、miR-224-3p表达。通过logistic回归模型分析脑梗死患者CAS不稳定的影响因素，进一步采用受试者操作特征（ROC）曲线分析其对脑梗死患者CAS斑块稳定情况的预测价值。结果不稳定组吸烟者占比、糖尿病患者占比、低密度脂蛋白胆固醇（LDL-C）、miR-125a-3p表达高于稳定组，miR-224-3p表达低于稳定组，差异有统计学意义（P＜0.05）。多因素分析显示，吸烟、糖尿病、LDL-C、miR-125a-3p、miR-224-3p均为脑梗死患者CAS斑块不稳定的影响因素（P＜0.05），5项联合预测脑梗死患者CAS斑块不稳定的ROC曲线下面积为0.915，灵敏度、特异度分别为84.00%、91.11%。结论脑梗死患者血清miR-125a-3p、miR-224-3p水平与CAS斑块不稳定有关，可联合吸烟、糖尿病和LDL-C对CAS斑块不稳定进行预测。

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	李星　　刘京锋　　李博

关键词 ：脑梗死, miR-125a-3p, miR-224-3p, 颈动脉粥样硬化, 斑块

Abstract：Objective To investigate the relationship between the expression of miR-125a-3p and miR-224-3p in serum and carotid atherosclerotic (CAS) plaque in cerebral infarction. Methods A total of 120 patients with cerebral infarction admitted to Beijing Hepingli Hospital from March 2019 to December 2021 were selected and divided into unstable group (75 cases) and stable group (45 cases) according to their CAS plaque stability. Clinical data of the two groups were collected and compared, and the expression of miR-125a-3p and miR-224-3p in serum of the two groups was detected by real-time fluorescent quantitative PCR. The influencing factors of CAS instability in patients with cerebral infarction were analyzed by logistic regression model, and the predictive value of CAS plaque plaque stability in patients with cerebral infarction was further analyzed by receiver operation characteristic (ROC) curve. Results The proportion of smokers, the proportion of diabetic mellitus patients, the level of low-density lipoprotein cholesterol (LDL-C), and the expression of miR-125a-3p in unstable group were higher than those in stable group, and the expression of miR-224-3p was lower than that in stable group, the differences were statistically significant (P＜0.05). Multivariate analysis showed that smoking, diabetes mellitus, LDL-C, miR-125a-3p, and miR-224-3p were all influencing factors of CAS plaque instability in patients with cerebral infarction (P＜0.05). The area under the ROC curve of the five items combined to predict CAS plaque instability in patients with cerebral infarction was 0.915, and the sensitivity and specificity were 84.00% and 91.11%, respectively. Conclusion Serum miR-125a-3p and miR-224-3p levels in patients with cerebral infarction are associated with CAS plaque instability, which can be predicted by combining smoking, diabetes mellitus, and LDL-C.

Key words： Cerebral infarction miR-125a-3p miR-224-3p Carotid atherosclerosis Plaque

基金资助:北京市卫生健康委员会首都卫生发展科研项目（首发2020-2-2241）。

通讯作者: 李博（1973.6-），女，主任医师；研究方向：脑血管病。

引用本文:

李星　　刘京锋　　李博. 血清miR-125a-3p、miR-224-3p表达与脑梗死患者颈动脉粥样硬化斑块的关系[J]. 中国医药导报, 2023, 20(26): 91-95.
LI Xing LIU Jingfeng LI Bo. Relationship between the expression of miR-125a-3p and miR-224-3p in serum and carotid atherosclerotic plaque in patients with cerebral infar-ction. 中国医药导报, 2023, 20(26): 91-95.

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https://www.yiyaodaobao.com.cn/CN/10.20047/j.issn1673-7210.2023.26.19 或 https://www.yiyaodaobao.com.cn/CN/Y2023/V20/I26/91