1.Department of Neonatology, Second Affiliated Hospital of Xian Medical College, Shaanxi Province, Xian 710038, China;
2.Central Laboratory, Second Affiliated Hospital of Xian Medical College, Shaanxi Province, Xian 710038, China
Abstract：Objective To study clinical effect of Qingre Xuanfei Ties in the treatment of recurrent infantile pneumonia. Methods One hundred and six infants with recurrent pneumonia in Second Affiliated Hospital of Xian Medical College from January 2016 to June 2021 were selected and divided into conventional group and experimental group according to random number table method, with fifty three cases in each group. The conventional group was treated with conventional western medicine, while the experimental group was treated with Qingre Xuanfei Ties as an assistant of conventional western medicine. Both groups were treated continuously for one week. Clinical effect, Chinese medicine syndrome score, inflammatory factors [interleukin-4 (IL-4), tumor necrosis factor-α (TNF-α), C reactive protein (CRP)], immune function [immunoglobulin (Ig)A, IgM, IgG], adverse reaction and recurrence of two groups were compared. Results Clinical effect of experimental group was better than that of conventional group, with a statistically significant difference (P＜0.05). Before treatment, there was no significant difference in Chinese medicine syndrome scores between two groups (P＞0.05). After treatment, Chinese medicine syndrome scores of two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). Before treatment, there were no significant differences in IL-4, TNF-α, and CRP levels between two groups (P＞0.05). After treatment, IL-4, TNF-α, and CRP levels of two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). Before treatment, there were no significant differences in the levels of IgA, IgM, and IgG between two groups (P＞0.05). After treatment, the levels of IgA, IgM, and IgG in the two groups were lower than those before treatment, and experimental group was lower than that conventional group, with statistically significant differences (P＜0.05). There were no significant difference between two groups in the incidence of adverse reactions and the recurrence rate (P＞0.05). Conclusion Qingre Xuanfei Ties is effective in the treatment of recurrent infantile pneumonia. It can reduce the score of Chinese medicine syndrome, reduce inflammatory reaction, improve immune function, and has high safety.
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