Relationship between serum soluble intercellular adhesion molecule-1，soluble CD163 levels and in-stent restenosis after percutaneous coronary intervention in patients with unstable angina pectoris
CHEN Yang WU Ningning PANG Shengfeng
Department of Cardiovascular Disease, Taizhou Hospital of Traditional Chinese Medicine, Jiangsu Province, Taizhou 225300, China
Abstract：Objective To investigate the relationship between serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble CD163 (sCD163) levels and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with unstable angina pectoris(UAP). Methods A total of 182 UAP patients who underwent PCI in Taizhou Hospital of Traditional Chinese Medicine , Jiangsu Province from January 2019 to February 2021 were selected and divided into ISR group (41 cases) and non-ISR group (141 cases) according to whether ISR occurred. The clinical data of the two groups were collected, and the serum levels of sICAM-1 and sCD163 were detected by enzyme-linked immunosorbent assay. Binary logistic regression was used to analyze the influencing factors of ISR in UAP patients after PCI. The receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum sICAM-1 and sCD163 levels for ISR in UAP patients after PCI. Results The levels of serum sICAM-1, sCD163, and low-density lipoprotein cholesterol (LDL-C) in the ISR group were higher than those in the non-ISR group, the stent length was longer than that in the non-ISR group, and the stent diameter was shorter than that in the non-ISR group (P＜0.05). Multivariate analysis showed that stent diameter (OR=0.877, 95%CI: 0.797-0.965), LDL-C (OR=1.006, 95%CI: 1.003- 1.009), sICAM-1 (OR=1.014, 95%CI: 1.006-1.023), and sCD163 (OR=1.121, 95%CI: 1.021-1.232) were independent influencing factors for ISR in UAP patients after PCI (P＜0.05). The results of ROC curve analysis showed that the area under the curve of serum sICAM-1 and sCD163 combined to predict ISR in UAP patients after PCI was higher than that of each index alone (P＜0.05). Conclusion Serum sICAM-1 and sCD163 levels are independent influencing factors of ISR in UAP patients after PCI, which can be used as predictors of ISR.
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