牛黄熄风胶囊治疗急性前循环脑梗死机械取栓患者的临床效果

doi:10.20047/j.issn1673-7210.2022.33.31

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摘要目的探讨牛黄熄风胶囊治疗急性前循环脑梗死机械取栓患者的临床效果。方法选取山东省潍坊市中医院2021年3月至12月收治的急性前循环脑梗死机械取栓患者84例，根据随机数字表法将其分为对照组和实验组，各42例。对照组在取栓术后予以常规西药治疗30 d，实验组在对照组的基础上给予口服牛黄熄风胶囊治疗30 d。比较两组术后即刻及术后30 d的美国国立卫生研究院卒中量表（NIHSS）评分、改良Rankin量表（mRS）评分、中医症状评分和血清S100β蛋白水平。比较两组治疗前及治疗后30 d的白细胞计数（WBC）、丙氨酸氨基转移酶（ALT）、肌酐（Cr）水平。比较两组疗效。结果术后即刻两组NIHSS评分、mRS评分、中医症状评分、血清S100β蛋白水平比较，差异无统计学意义（P ＞ 0.05）；术后30 d两组NIHSS评分、mRS评分、中医症状评分、血清S100β蛋白水平均低于术后即刻，且实验组低于对照组，差异有统计学意义（P ＜ 0.05）。治疗前及治疗后30 d两组WBC、ALT、Cr水平组间、组内比较，差异无统计学意义（P ＞ 0.05）。实验组疗效优于对照组，差异有统计学意义（P ＜ 0.05）。结论牛黄熄风胶囊应用于急性前循环脑梗死机械取栓患者可有效促进神经功能缺损的改善，且无明显不良反应。

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	李阳1 周虹2 邹云涛2 张伦忠2

关键词 ：急性前循环脑梗死, 机械取栓, 牛黄熄风胶囊, 疗效观察

Abstract：Objective To explore the clinical effect of Niuhuang Xifeng Capsules in the treatment of mechanical thrombectomy patients with acute anterior circulation cerebral infarction. Methods Eighty-four mechanical thrombectomy patients with acute anterior circulation cerebral infarction treated in Weifang Hospital of Traditional Chinese Medicine in Shandong Province from March to December 2021 were selected and divided into control group and experimental group according to random number table method, 42 cases in each group. The control group was treated with conventional western medicine for 30 days after thrombectomy, the experimental group was given Niuhuang Xifeng Capsules for 30 days after treatment on the basis of the control group. National Institute of Health stroke scale (NIHSS) score, modified Rankin scale (mRS) score, traditional Chinese medicine symptom score and serum S100β protein level were compared between the two groups immediately after operation and 30 days after operation. The levels of white blood cell count (WBC), alanine aminotransferase (ALT), and creatinine (Cr) before treatment and 30 days after treatment were compared between the two groups. The efficacy of the two groups was compared. Results Immediately after operation, there were no significant differences in NIHSS score, mRS score, traditional Chinese medicine symptom score, and serum S100β protein level between the two groups (P ＞ 0.05). Thirty days after operation, NIHSS score, mRS score, traditional Chinese medicine symptom score, and serum S100β protein level of two groups were lower than those immediately after operation, and experimental group was lower than that control group, the differences were statistically significant (P ＜ 0.05). Before treatment and 30 days after treatment, there were no significant differences in WBC, ALT, and Cr levels between and within the two groups (P ＞ 0.05). The effect of experimental group was better than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Niuhuang Xifeng Capsules can effectively promote the improvement of neural function defect in mechanical thrombectomy patients with acute anterior circulation cerebral infarction, and there is no obvious adverse reaction.

Key words： Acute anterior circulation cerebral infarction Mechanical thrombectomy Niuhuang Xifeng Capsules Effect observation

基金资助:山东省中医药科技项目（2020M143）；
山东省潍坊市卫生健康委员会中医药科研项目[2021年（第四类）第042号]。

通讯作者: 张伦忠（1964-），男，主任医师；研究方向：脑血管病。

作者简介: 李阳（1997-），男，山东中医药大学第一临床医学院2020级中医内科学专业在读硕士研究生；研究方向：脑血管病。

引用本文:

李阳1 周虹2 邹云涛2 张伦忠2. 牛黄熄风胶囊治疗急性前循环脑梗死机械取栓患者的临床效果[J]. 中国医药导报, 2022, 19(33): 138-142.
LI Yang1 ZHOU Hong2 ZOU Yuntao2 ZHANG Lunzhong2. Clinical effect of Niuhuang Xifeng Capsules in the treatment of mechanical thrombectomy patients with acute anterior circulation cerebral infarction. 中国医药导报, 2022, 19(33): 138-142.

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