木丹颗粒联合硫辛酸注射液治疗糖尿病足的临床效果

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摘要目的研究木丹颗粒联合硫辛酸注射液治疗糖尿病足的临床效果。方法选取2019年4月至2020年10月海南医学院第二附属医院收治的糖尿病足患者98例，通过随机数字表法将其分为对照组（硫辛酸注射液治疗）和试验组（对照组的基础上联合木丹颗粒治疗），各49例。两组均治疗4周。比较两组疗效，治疗前后血糖指标[糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后2h血糖（2hPG）]、足背动脉血流动力学指标[血管内径、阻力指数（RI）、血流流速、搏动指数（PI）]、炎症因子指标[超敏C反应蛋白（hs-CRP）、白细胞介素-6（IL-6）、降钙素原（PCT）]及不良反应发生率。结果试验组临床疗效高于对照组（P ＜ 0.05）。治疗4周后，两组HbA1c、FBG、2hPG、hs-CRP、IL-6、PCT水平均较治疗前降低，且试验组低于对照组（P ＜ 0.05）。两组治疗4周后血管内径、RI、血流流速、PI均较治疗前升高，且试验组高于对照组（P ＜ 0.05）。两组不良反应发生率比较，差异无统计学意义（P ＞ 0.05）。结论采用木丹颗粒和硫辛酸注射液治疗糖尿病足，效果确切，可有效控制血糖，改善炎症反应和足背动脉血流动力学，安全可靠。

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	符芳盈1 陈玲1 翁育才1 陈金逸2

关键词 ：木丹颗粒, 硫辛酸注射液, 糖尿病足, 疗效, 不良反应

Abstract：Objective To study the clinical effect of Mudan Granules combined with Thioctic Acid Injection in the treatment of diabetic foot. Methods A total of 98 patients with diabetic foot treated in the Second Affiliated Hospital of Hainan Medical College from April 2019 to October 2020 were selected. The patients were divided into control group (treated with Thioctic Acid Injection) and experimental group (treated with Mudan Granules on the basis of control group) by random number table method, with 49 cases in each group. The two groups were treated for 4 weeks. The curative effect, blood glucose index (glycosylated hemoglobin [HbA1c], fasting blood glucose [FBG], 2 h postprandial blood glucose [2hPG]), hemodynamic index of dorsalis pedis artery (vessel diameter, resistance index [RI], blood flow velocity, pulsatility index [PI]), inflammatory factor index (high sensitivity C-reactive protein [hs-CRP], interleukin-6 [IL-6], procalcitonin [PCT]) before and after treatment, and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the experimental group was higher than that of the control group (P ＜ 0.05). After four weeks of treatment, the levels of HbA1c, FBG, 2hPG, hs-CRP, IL-6, and PCT decreased compared with before treatment in both groups, and those in the experimental group were lower than the control group (P ＜ 0.05). After four weeks of treatment, the vascular diameter, RI, blood flow velocity, and PI increased compared with before treatment in both groups, and those in the experimental group were higher than the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion It is effective to treat diabetic foot with Mudan Granules and Thioctic Acid Injection. It can effectively control blood sugar, improve inflammatory reaction and hemodynamics of dorsal artery of foot, and is safe and reliable.

Key words： Mudan Granules Thioctic Acid Injection Diabetic foot Curative effect Adverse reaction

基金资助:海南省卫生和计划生育委员会卫生计生行业科研项目（18A201136）。

引用本文:

符芳盈1 陈玲1 翁育才1 陈金逸2. 木丹颗粒联合硫辛酸注射液治疗糖尿病足的临床效果[J]. 中国医药导报, 2022, 19(3): 67-70.
FU Fangying1 CHEN Ling1 WENG Yucai1 CHEN Jinyi2. Clinical efficacy of Mudan Granules combined with Thioctic Acid Injection in the treatment of diabetic foot#br#. 中国医药导报, 2022, 19(3): 67-70.

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