Visualization analysis of hotspots of research on bone tumor basedon CiteSpace and VOSviewer
ZHANG Qiang1 TIAN Shengyuan1 LI Qing2#br#
1.Clinical Medical College, Guizhou Medical University, Guizhou Province, Guiyang 550004, China;
2.Department of Trauma Orthopedics, Affiliated Hospital of Guizhou Medical University, Guizhou Province, Guiyang 550004, China
Abstract：Objective To analyze the research hotspots and trends of bone tumor with knowledge graph. Methods CiteSpace and VOSviewer software were used to search the literature related to bone tumor from 2000 to 2020 on Web of Science, and the bibliometric analysis was performed. According to the results, the annual publication volume, cooperation network of countries/regions and institutions, author cooperation network, keyword co-occurrence and clustering, and co-cited literature clustering were drawn and analyzed. Results A total of 2 852 papers were included in the study with a steady increase of publications; a total of 290 authors were included in the author’s cooperation network, represented by Xiao Jianru; a total of 285 institutions were included in institutional cooperation network, represented by Shanghai Jiao Tong University; the keyword clustering showed that research hotspots focused on the fields of osteosarcoma, bone metastases, apoptosis, and other related fields; the co-citation literature clustering showed that the current research focused on proliferation, STAT3, and signaling pathway. Conclusion The visual analysis of knowledge graph indicates that osteosarcoma, bone metastasis and apoptosis are the research hotspots, providing a certain reference for future researches.
张强1 田晟源1 李青2. 基于CiteSpace及VOSviewer的骨肿瘤研究热点的可视化分析[J]. 中国医药导报, 2022, 19(29): 11-15.
ZHANG Qiang1 TIAN Shengyuan1 LI Qing2. Visualization analysis of hotspots of research on bone tumor basedon CiteSpace and VOSviewer. 中国医药导报, 2022, 19(29): 11-15.
[1] 宋寒冰，杨玉赫，沈小钰，等.中医药治疗骨肿瘤研究进展[J].辽宁中医药大学学报，2018，20（6）：176-179.
[2] Hiraga T. Bone metastasis： Interaction between cancer cells and bone microenvironment [J]. Oral Biosci，2019，61（2）：95-98.
[3] Xu M，Xu S，Yu X. Marginal resection for osteosarcoma with effective neoadjuvant chemotherapy：long-term outcomes [J]. World J Surg Oncol，2014，12：341.
[4] Ogura K，Sakuraba M，Miyamoto S，et al. Pelvic ring reconstruction with a double-barreled free vascularized fibula graft after resection of malignant pelvic bone tumor [J]. Arch Orthop Trauma Surg，2015，135（5）：619-625.
[5] Chen C，Ibekwe-Sanjuan F，Hou J. The Structure and Dynamics of Co-Citation Clusters： A Multiple-Perspective Co-Citation Analysis [J]. J Assoc Inf Sci Technol，2010， 61（7）：1386-1409.
[6] Synnestvedt MB，Chen C，Holmes JH. CiteSpace Ⅱ： visualization and knowledge discovery in bibliographic databases [J]. AMIA Annu Symp Proc，2005：724-728.
[7] Perianesrodriguez A，Waltman L，Eck N，et al. Constructing bibliometric networks：A comparison between full and fractional counting [J]. J Informetrics，2016，10（4）：1178-1195.
[8] Waltman L，Eck NJV. A smart local moving algorithm for large-scale modularity-based community detection [J]. Euro Physical J B，2013，86（11）：1-14.
[9] Lindsey BA，Markel JE，Kleinerman ES. Osteosarcoma Overview [J]. Rheumatol Ther，2017，4（1）：25-43.
[10] Eccles SA，Welch DR. Metastasis： recent discoveries and novel treatment strategies [J]. Lancet，2007，369（9574）：1742-1757.
[11] Pradelli E，Karimdjee-Soilihi B，Michiels JF，et al. Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs [J]. Intern J Cancer，2010， 125（11）：2586-2594.
[12] Hughes DP. Strategies for the targeted delivery of therapeutics for osteosarcoma [J]. Expert Opin Drug Deliv，2009，6（12）：1311-1321.
[13] 袁振超.微波消融治疗骨肿瘤的应用研究进展[J].中国骨与关节杂志，2018，7（5）：368-373.
[14] 郭卫，牛晓辉，肖建如，等.骨肉瘤临床循证诊疗指南[J].中华骨与关节外科杂志，2018，11（4）：288-301.
[15] 张健烽.骨肉瘤治疗的研究进展[J].浙江医学，2019，41（7）：723-730.
[16] Ogura K，Sakuraba M，Miyamoto S，et al. Pelvic ring reconstruction with a double-barreled free vascularized fibula graft after resection of malignant pelvic bone tumor [J]. Archives of Orthopaedic & Trauma Surgery，2015， 135（5）：619-625.
[17] Ge YW，Liu XL，Yu DG，et al. Graphene-modified CePO4 nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability [J]. J Nanobiotechnology，2021，19（1）：11.
[18] Chen Y，Zheng Z，Zhou R，et al. Developing a strontium-releasing graphene oxide-/collagen-based organic-inorganic nanobiocomposite for large bone defect regeneration via MAPK signaling pathway [J]. ACS Appl Mater Interfaces，2019，11（17）：15986-15997.
[19] Xu C，Ma B，Peng J，et al. Tricalcium silicate/graphene oxide bone cement with photothermal properties for tumor ablation [J]. J Mater Chem B，2019，7（17）：2808-2818.
[20] Zhou Y，Yang D，Yang Q，et al. Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma [J]. Nat Commun，2020，11（1）：6322.
[21] Wu W，Jing D，Meng Z，et al. FGD1 promotes tumor progression and regulates tumor immune response in osteosarcoma via inhibiting PTEN activity [J]. Theranostics，2020，10（6）：2859-2871.
[22] Wang K，Gu Y，Liao Y，et al. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain [J]. J Clin Invest，2020，130（7）：3603-3620.
[23] Zhong B，Shi D，Wu F，et al. Dynasore suppresses cell proliferation，migration，and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma [J]. Cell Death Dis，2019，10（10）：687.
[24] Wang Z，Wang C，Zuo D，et al. Attenuation of STAT3 Phosphorylation Promotes Apoptosis and Chemosensitivity in Human Osteosarcoma Induced by Raddeanin A [J]. Int J Biol Sci，2019，15（3）：668-679.
[25] Mao M，Zhang T，Wang Z，et al. Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo [J]. Biochim Biophys Acta Mol Basis Dis，2019，1865（6）：1214-1225.
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