Epigenetic regulation and its mechanism of action in bronchial asthma research progress
YANG Yang1 SU Chang2 ZHANG Qiuyan3 HUANG Shuchun1 KUANG Huifang1#br#
1.College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
2.Xiangxing College, Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China;
3.School Hospital of Hunan University of Chinese Medicine, Hunan Province, Changsha 410208, China
Abstract：Bronchial asthma is a common respiratory disease in the world, with a high incidence and recurrent disease, which seriously affects human health. In recent years, epigenetic mechanisms mediating the pathological mechanism of bronchial asthma induced by exposure to allergens, air pollutants, viral infections, and other environmental factors have attracted much attention, providing a new way to elucidate the interaction between genes and the environment. This article reviews the roles and mechanisms of DNA methylation, histone methylation, histone acetylation, and non-coding RNA in the occurrence and development of asthma, in order to clarify the epigenetic regulation mechanism of asthma and provide a new target for the treatment of asthma.
[1] Huang K，Yang T，Xu J，et al. Prevalence，risk factors，and management of asthma in China：a national cross-sectional study [J]. Lancet，2019，394（10196）：407-418.
[2] Tyler SR，Bunyavanich S. Leveraging -omics for asthma endotyping [J]. J Allergy Clin Immunol，2019，144（1）：13-23.
[3] Pividori M，Schoettler N，Nicolae DL，et al. Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma：genome-wide and transcriptome-wide studies [J]. Lancet Respir Med，2019，7（6）：509-522.
[4] Reese SE，Xu CJ，Den dekker HT，et al. Epigenome-wide meta-analysis of DNA methylation and childhood asthma [J]. J Allergy Clin Immunol，2019，143（6）：2062-2074.
[5] Reese SE，Xu CJ，den Dekker HT，et al. Epigenome-wide meta-analysis of DNA methylation and childhood asthma[J]. J Allergy Clin Immunol，2019，143（6）：2062-2074.
[6] Larouche M，Gagné-ouellet V，Boucher-lafleur AM，et al. Methylation profiles of IL33 and CCL26 in bronchial epithelial cells are associated with asthma [J]. Epigenomics，2018，10（12）：1555-1568.
[7] Hudon thibeault AA，Laprise C. Cell-Specific DNA Methylation Signatures in Asthma [J]. Genes （Basel），2019，10（11）：932.
[8] Chen X，Lin H，Yang D，et al. Early-life undernutrition reprograms CD4（+）T-cell glycolysis and epigenetics to facilitate asthma [J]. J Allergy Clin Immunol，2019，143（6）：2038-2051.e12.
[9] Alashkar Alhamwe B，Alhamdan F，Ruhl A，et al. The role of epigenetics in allergy and asthma development [J]. Curr Opin Allergy Clin Immunol，2020，20（1）：48-55.
[10] Agache I，Eguiluz-Gracia I，Cojanu C，et al. Advances and highlights in asthma in 2021 [J]. Allergy，2021，76（11）：3390-3407.
[11] Bellanti JA. Genetics/epigenetics/allergy：The gun is loaded … but what pulls the trigger? [J]. Allergy Asthma Proc，2019，40（2）：76-83.
[12] Michael AK，Thom?覿 NH. Reading the chromatinized genome [J]. Cell，2021，184（14）：3599-3611.
[13] Talbert PB，Henikoff S. Histone variants at a glance [J]. J Cell Sci，2021，134（6）：jcs244749.
[14] Zhang Y，Sun Z，Jia J，et al. Overview of Histone Modification [J]. Adv Exp Med Biol，2021，1283：1-16.
[15] Mondejar-parre?觡o G，Perez-vizcaino F，Cogolludo A. Kv7 Channels in Lung Diseases [J]. Front Physiol，2020，11：634.
[16] Sun Q，Liu L，Wang H，et al. Constitutive high expression of protein arginine methyltransferase 1 in asthmatic airway smooth muscle cells is caused by reduced microRNA-19a expression and leads to enhanced remodeling [J]. J Allergy Clin Immunol，2017，140（2）：510-524.e3.
[17] Yu Q，Yu X，Zhong X，et al. Melatonin modulates airway smooth muscle cell phenotype by targeting the STAT3/Akt/GSK-3β pathway in experimental asthma [J]. Cell Tissue Res，2020，380（1）：129-142.
[18] Shirvaliloo M. The unfavorable clinical outcome of COVID-19 in smokers is mediated by H3K4me3，H3K9me3 and H3K27me3 histone marks [J]. Epigenomics，2022，14（3）：153-162.
[19] Von knethen A，Heinicke U，Weigert A，et al. Histone Deacetylation Inhibitors as Modulators of Regulatory T Cells [J]. Int J Mol Sci，2020，21（7）：2356.
[20] Kasinath V，Beck C，Sauer P，et al. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications [J]. Science，2021，371（6527）：eabc3393.
[21] Xu YH，Liu K，Yan J，et al. Function and mechanism of histone demethytransferase Jmjd3 mediated regulation of Th1/Th2 balance through epigenetic modification in pre-eclampsia[J]. Zhonghua Bing Li Xue Za Zhi，2020，49（10）：1041-1045.
[22] Laugesen A，H?覬jfeldt JW，Helin K. Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation [J]. Mol Cell，2019，74（1）：8-18.
[23] Liu B，Sun H，Wang J，et al. Potential role for EZH2 in promotion of asthma through suppression of miR-34b transcription by inhibition of FOXO3 [J]. Lab Invest，2021， 101（8）：998-1010.
[24] Zwinderman M，De weerd S，Dekker FJ. Targeting HDAC Complexes in Asthma and COPD [J]. Epigenomes，2019， 3（3）：19.
[25] Lou L，Tian M，Chang J，et al. MiRNA-192-5p attenuates airway remodeling and autophagy in asthma by targeting MMP-16 and ATG7 [J]. Biomed Pharmacother，2020，122：109692.
[26] Huang Z，Liang N，Go?觡i S，et al. The corepressors GPS2 and SMRT control enhancer and silencer remodeling via eRNA transcription during inflammatory activation of macrophages [J]. Mol Cell，2021，81（5）：953-968.e9.
[27] Thatikonda S，Pooladanda V，Sigalapalli DK，et al. Piperlongumine regulates epigenetic modulation and alleviates psoriasis-like skin inflammation via inhibition of hyperproliferation and inflammation [J]. Cell Death Dis，2020， 11（1）：21.
[28] Kaur G，Bagam P，Pinkston R，et al. Cigarette smoke-induced inflammation：NLRP10-mediated mechanisms [J]. Toxicology，2018，398-399：52-67.
[29] Yamashita M，Ukai-tadenuma M，Kimura M，et al. Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus [J]. J Biol Chem，2002，277（44）：42399-42408.
[30] Yang MW，Tao LY，Jiang YS，et al. Perineural Invasion Reprograms the Immune Microenvironment through Cholinergic Signaling in Pancreatic Ductal Adenocarcinoma [J]. Cancer Res，2020，80（10）：1991-2003.
[31] Boivin V，Faucher-giguère L，Scott M，et al. The cellular landscape of mid-size noncoding RNA [J]. Wiley Interdiscip Rev RNA，2019，10（4）：e1530.
[32] Robinson ek，Covarrubias S，Carpenter S. The how and why of lncRNA function：An innate immune perspective [J]. Biochim Biophys Acta Gene Regul Mech，2020，1863（4）：194419.
[33] Zhang XY，Chen ZC，LI N，et al. Exosomal transfer of activated neutrophil-derived lncRNA CRNDE promotes proliferation and migration of airway smooth muscle cells in asthma [J]. Hum Mol Genet，2022，31（4）：638-650.
[34] Qiu YY，Wu Y，Lin MJ，et al. LncRNA-MEG3 functions as a competing endogenous RNA to regulate Treg/Th17 balance in patients with asthma by targeting microRNA-17/ RORγt [J]. Biomed Pharmacother，2019，111：386-394.
[35] Fan M，Xu J，Xiao Q，et al. Long non-coding RNA TCF7 contributes to the growth and migration of airway smooth muscle cells in asthma through targeting TIMMDC1/Akt axis [J]. Biochem Biophys Res Commun，2019，508（3）：749-755.
[36] Han X，Huang S，Xue P，et al. LncRNA PTPRE-AS1 modulates M2 macrophage activation and inflammatory diseases by epigenetic promotion of PTPRE [J]. Sci Adv，2019，5（12）：eaax9230.
[37] Zhang XY，Tang XY，Li N，et al. GAS5 promotes airway smooth muscle cell proliferation in asthma via controlling miR-10a/BDNF signaling pathway [J]. Life Sci，2018， 212：93-101.
[38] Elkashef S，Ahmad SE，Soliman Y，et al. Role of microRNA-21 and microRNA-155 as biomarkers for bronchial asthma [J]. Innate Immun，2021，27（1）：61-69.
[39] Ni FF，Liu GL，Jia SL，et al. Function of miR-24 and miR-27 in Pediatric Patients With Idiopathic Nephrotic Syndrome [J]. Front Pediatr，2021，9：651544.
[40] Kaczmarek KA，Clifford RL，Knox AJ. Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma [J]. Chest，2019，155（4）：816-824.
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