Abstract：Objective To study the effect and adverse reactions of Sodium Valproate Sustained Release Tablets and Levetiracetam Tablets in children with primary epilepsy. Methods A total of 100 children with primary epilepsy admitted to the Second People’s Hospital of Lianyungang, Jiangsu Province from January 2020 to February 2021 were selected as the study objects. According to random number table method, they were divided into experimental group and control group, with 50 cases in each group. The control group received Sodium Valproate Sustained Release Tablets, and the experimental group received Levetiracetam Tablets. Blood drug concentration, clinical effect, electroencephalogram evaluation results, and the occurrence of adverse reactions were observed and compared between two groups after six months of treatment. Results The average blood drug concentration of control group was (69.73±30.15) μg/ml; and the average blood drug concentration of experimental group was (13.92±4.76) mg/ml. The total effective rate of experimental group was higher than that of control group, and the difference was statistically significant (P < 0.05). The correction rate of electroencephalogram in experimental group was higher than that in control group, and the difference was statistically significant (P < 0.05). There was no statistical difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Levetiracetam Tablets monotherapy is superior to Sodium Valproate Sustained Release Tablets in the treatment of children with primary epilepsy, and has certain safety.
陆琳 马素青▲ 毕金珠. 丙戊酸钠与左乙拉西坦治疗儿童原发性癫痫的效果比较[J]. 中国医药导报, 2022, 19(14): 84-87.
LU Lin MA Suqing▲ BI Jinzhu. Effect comparison of Sodium Valproate Sustained Release Tablets and Levetiracetam Tablets in the treatment of children with primary epilepsy. 中国医药导报, 2022, 19(14): 84-87.
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