Research progress of lncRNA PVT1 in orthopedic diseases#br#
HU Mingyue1 PENG Sha2 YAO Nan3 REN Wei3 HU Zixuan3 HUANG Dan’e3
1.College of Pharmacy, Guangdong Lingnan Institute of Technology, Guangdong Province, Guangzhou 510663, China;
2.The Fifth Clinical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510095, China;
3.Guangdong Provincial Engineering Technology Research Institute of Traditional Chinese Medicine Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine, Guangdong Province, Guangzhou 510095, China
Abstract：In today’s aging society, the incidence rate of orthopedic diseases related to the elderly is increasing, which seriously threatens human health. Long non-coding RNA (lncRNA) belongs to non-coding RNA, which plays an important role in the occurrence and development of many diseases. Plasmacytoma variant translocation gene 1 (PVT1) is one of the lncRNAs, which plays an important role in orthopedic diseases. It is expected to become a therapeutic target for osteopathic diseases such as osteoarthritis, rheumatoid arthritis and asteosarcoma, as well as a biomarker for diagnosis, prognosis, and drug resistance. This article reviews the research progress of PVT1 in orthopedic diseases at home and abroad, so as to provide theoretical basis for basic research and clinical practice of orthopedics.
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