miR-150与肺部疾病关系的研究进展

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摘要随着大气污染的加重，环境中有害因子增多，近年来呼吸系统疾病的患病率有着逐年增高的趋势。研究表明，微RNA（miRNA）以调控基因表达的方式参与了机体很多的病理生理过程。miR-150作为miRNA家族中的一员，已被证实与肺癌、急性肺损伤、肺纤维化、肺动脉高压以及慢性阻塞性肺疾病、胸腔积液等相关。miR-150的上调或下调可有效调节这些疾病的生物学过程，提示miR-150与上述疾病的发生、发展及预后密切相关，可能为呼吸系统疾病的诊断和治疗提供新的靶点。本文将针对miR-150与肺部疾病关系的研究进展进行综述。

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	蔡茜1 陈思睿2 朱应群1

关键词 ：微RNA, 肺部疾病, 基因调控, miR-150

Abstract：With the aggravation of air pollution and the increase of harmful factors in the environment, the prevalence of respiratory diseases has been increasing year by year in recent years. Studies have shown that micrornas (miRNA) are involved in many pathophysiological processes of the body by regulating gene expression. miR-150 is a member of miRNA family, it has been proven to be associated with lung cancer, acute lung injury, pulmonary fibrosis, pulmonary hypertension, chronic obstructive pulmonary disease, pleural effusion and so on. Up-regulation or down-regulation of miR-150 can effectively regulate the biological process of these diseases, it is suggested that miR-150 is closely related to the occurrence, development and prognosis of the above-mentioned diseases, may provide new targets for the diagnosis and treatment of respiratory diseases. This paper will review the research progress on the relationship between miR-150 and lung diseases.

Key words： MicroRNA Lung disease Gene regulation miR-150

基金资助:湖南省卫生健康委科研计划重点课题资助项目（A20182005）；
湖南省长沙市自然科学基金资助项目（kq201 4009）。

通讯作者: 朱应群（1967.12-），女，硕士，主任医师；研究方向：慢性阻塞性肺疾病。

作者简介: 蔡茜（1978.10-），女，硕士，副主任医师；研究方向：慢性阻塞性肺疾病、肺动脉高压。

引用本文:

蔡茜1 陈思睿2 朱应群1. miR-150与肺部疾病关系的研究进展[J]. 中国医药导报, 2021, 18(34): 51-54.
CAI Qian1 CHEN Sirui2 ZHU Yingqun1. Research progress on the relationship between miR-150 and pulmonary diseases#br#. 中国医药导报, 2021, 18(34): 51-54.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I34/51

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