细胞焦亡机制及其在多种肾脏病中的作用

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摘要细胞焦亡是近年新发现的一种促炎性程序性细胞死亡方式，可由炎症小体、半胱天冬酶-1、人半胱天冬酶-4/5、鼠半胱天冬酶-11及其下游反应因子gasdermin家族蛋白D（GSDMD）共同介导。当机体受到外来物质侵害时可启动细胞焦亡的上游反应原件，促使GSDMD结构改变，较多的GSDMD N端坏死域聚集后形成一种膜成孔活性物质引起细胞膜的损害，使炎症因子如白细胞介素-18（IL-18）及IL-1β等释放从而产生炎症反应。细胞焦亡机制在晶体相关性肾病、缺血再灌注肾损伤、糖尿病肾病及肾脏纤维化等方面均有所参与。本文针对细胞焦亡的具体机制及其在多种肾脏疾病发生发展中的作用进行综述。

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	孙晓怡1 姜玉勤1 唐余燕2 刘何晶1 陆迅3 魏明刚2

关键词 ：细胞焦亡, 肾脏疾病, NLRP3炎症小体

Abstract：Pyroptosis is a newly discovered method of pro-inflammatory programmed cell death in recent years, which can be caused by inflammasome, caspase-1, human caspase-4/5, and mouse caspase- 11, and its downstream response factor gasdermin D (GSDMD) co-mediated. When the body is invaded by foreign substances, it can initiate the upstream reaction element of pyroptosis, which promotes the structural change of GSDMD. After more GSDMD N-terminal necrotic domains accumulate to form a membrane pore-forming active substance that causes cell membrane damage and causes inflammatory factors, such as interleukin-18 (IL-18) and IL-1β are released to cause inflammation. The mechanism of pyroptosis is involved in crystal-related nephropathy, ischemia-reperfusion kidney injury, diabetic nephropathy, and renal fibrosis. This article will review the specific mechanism of pyroptosis and its role in the occurrence and development of a variety of kidney diseases.

Key words： Pyroptosis Kidney disease NLRP3 inflammasome

基金资助:国家自然科学基金资助项目（81673896）；
江苏省苏州市科技局应用基础研究项目（SYSD2019205、SYSD2019210、SYS2020119）。

通讯作者: 魏明刚（1975.5-），男，博士，主任中医师；研究方向：中西医结合肾病。

作者简介: 孙晓怡（1996.2-），女，苏州大学附属第一医院2019级肾内科学专业在读硕士研究生；研究方向：肾内科。

引用本文:

孙晓怡1 姜玉勤1 唐余燕2 刘何晶1 陆迅3 魏明刚2. 细胞焦亡机制及其在多种肾脏病中的作用[J]. 中国医药导报, 2021, 18(33): 53-56.
SUN Xiaoyi1 JIANG Yuqin1 TANG Yuyan2 LIU Hejing1 LU Xun3 WEI Minggang2. Mechanism of pyroptosis and its role in various kidney diseases#br#. 中国医药导报, 2021, 18(33): 53-56.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I33/53

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