Clinical effect of Dingchuan Decoction in the treatment of asthma-chronic obstructive pulmonary disease overlap syndrome with syndrome of phlegm heat obstructing lung#br#
LI Yue1 ZHENG Lan1 GAO Yue2
1.Department of Pulmonary Diseases, Hubei Provincial Hospital of TCM Affiliated Hospital of Hubei University of Chinese Medicine Hubei Academy of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China;
2.Department of Pharmacy, Hubei Provincial Hospital of TCM Affiliated Hospital of Hubei University of Chinese Medicine Hubei Academy of Traditional Chinese Medicine, Hubei Province, Wuhan 430061, China
Abstract：Objective To investigate the clinical effect of Dingchuan Decoction in the treatment of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) with syndrome of phlegm heat obstructing lung. Methods A total of 95 ACOS patients with syndrome of phlegm heat obstructing lung admitted to Hubei Provincial Hospital of TCM from January 2018 to September 2020 were selected. According to random number table method, they were divided into control group (47 cases) and study group (48 cases). The control group was treated with routine treatment and Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation, and the study group was treated with Dingchuan Decoction on the basis of control group. Both groups were treated for 3 months. The clinical efficacy, inflammatory factor, lung function, clinical symptom score and incidence of adverse reactions were compared between the two groups. Results After treatment, the total effective rate in the study group was higher than that in the control group (P ＜ 0.05). After treatment, interleukin-6, interleukin-10, and high-sensitivity C-reactive protein in the two groups were lower than those before treatment, and study group was lower than control group (P ＜ 0.05). After treatment, forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and FEV1/FVC in the two groups were higher than those before treatment, and study group was higher than control group (P ＜ 0.05). After treatment, asthma control test scores in the two groups were higher than those before treatment, and the study group was higher than the control group (P ＜ 0.05); chronic obstructive pulmonary disease assessment test scores in the two groups were lower than those before treatment, and the study group was lower than the control group (P ＜ 0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Dingchuan Decoction has a significant curative effect in the curative of ACOS with syndrome of phlegm heat obstructing lung, which can effectively improve the clinical symptoms, lung function and inflammatory factor levels of patients, with good safety and high clinical application value.
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