荜铃胃痛颗粒联合四联疗法治疗幽门螺杆菌感染阳性慢性萎缩性胃炎的效果

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摘要目的探讨荜铃胃痛颗粒联合四联疗法治疗幽门螺杆菌（Hp）感染阳性慢性萎缩性胃炎的效果。方法选取2019年3月至2020年3月安徽省第二人民医院收治的110例Hp阳性慢性萎缩性胃炎患者，采用信封抽签法将患者分为对照组（四联疗法治疗，55例）和观察组（荜铃胃痛颗粒联合四联疗法治疗，55例）。两组均治疗4个月。对比两组疗效、症状积分、Hp根除率、相关血清指标，记录两组安全性。结果观察组临床总有效率高于对照组（P ＜ 0.05）。观察组Hp根除率高于对照组（P ＜ 0.05）。治疗后，观察组胃脘痛、胃脘胀满、脉弦、嗳气等症状积分以及白细胞介素-4、肿瘤坏死因子-α低于低于对照组（P ＜ 0.05），γ干扰素高于对照组（P ＜ 0.05）。两组不良反应发生率比较，差异无统计学意义（P ＞ 0.05）。结论荜铃胃痛颗粒联合四联疗法治疗Hp阳性慢性萎缩性胃炎，效果确切，可促进症状改善，提高Hp根除率，改善炎症水平。

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	洪珊珊1 黄家惠1 徐少军2

关键词 ：慢性萎缩性胃炎, 荜铃胃痛颗粒, 幽门螺杆菌阳性, 四联疗法, 疗效

Abstract：Objective To investigate the effect of Biling Weitong Granules combined with quadruple therapy in the treatment of Helicobacter pylori (Hp) infection positive chronic atrophic gastritis. Methods A total of 110 Hp-positive patients with chronic atrophic gastritis admitted to Anhui No.2 Provincial People’s Hospital from March 2019 to March 2020 were selected, and the patients were divided into control group (quadruple therapy, 55 cases) and observation group (Biling Weitong Granules combined with quadruple therapy, 55 cases) by envelope lottery. Both groups were treated for four months. Efficacy, symptom score, Hp eradication rate and related serum indexes were compared between the two groups, and the safety of the two groups was recorded. Results The total clinical effective rate of observation group was higher than control group (P ＜ 0.05). The eradication rate of Hp in observation group was higher than that in control group (P ＜ 0.05). After treatment, the scores of epigastric pain, epigastric fullness, pulse string, belching and other symptoms, interleukin-4, tumor necrosis factor -α in the observation group were lower than those in the control group (P ＜ 0.05), and interferon γ was higher than that in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Biling Weitong Granules combined with quadruple therapy for the treatment of Hp-positive chronic atrophic gastritis has a definite effect, which can promote the improvement of symptoms, improve the eradication rate of Hp and improve the level of inflammation.

Key words： Chronic atrophic gastritis Biling Weitong Granules Helicobacter pylori positive Quadruple therapy Curative effect

基金资助:安徽省高校科学研究一般项目（2020ZR12925B 002）。

通讯作者: 黄家惠（1990.10-），女，硕士；研究方向：急慢性肝病的基础与临床。

作者简介: 洪珊珊（1989.4-），女，硕士；研究方向：幽门螺旋杆菌感染。

引用本文:

洪珊珊1 黄家惠1 徐少军2. 荜铃胃痛颗粒联合四联疗法治疗幽门螺杆菌感染阳性慢性萎缩性胃炎的效果[J]. 中国医药导报, 2021, 18(29): 122-125.
HONG Shanshan1 HUANG Jiahui1 XU Shaojun2. Effect of Biling Weitong Granules combined with quadruple therapy on chronic atrophic gastritis with positive Helicobacter pylori infection. 中国医药导报, 2021, 18(29): 122-125.

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