Abstract：Objective To study the effect of Buyang Huanwu Decoction on hemorheology and platelet aggregation in hyperlipidemia rats. Methods Forty 2.5-month-old clean-grade male SD rats weighing about 240 g were selected. Ten rats were randomly fed ordinary diet as blank group, and the other 40 rats were fed high-fat diet for four weeks to create hyperlipidemia model. According to random number table method, they were divided into Buyang Huanwu Decoction high-dose group (14.0 g/kg), Buyang Huanwu Decoction low-dose group (3.5 g/kg), Simvastatin control group (0.004 g/kg) and model group, with ten rats in each group. Except blank group and model group were given distilled water, the other groups were given relevant drugs by intragastric administration for four weeks. The plasma total cholesterol, triglyceride, low density lipoprotein cholesterin, whole blood viscosity, plasma viscosity, 6-keto-prostaglandin F1α, thromboxane B2, thromboxane A2, prostacyclin, cyclic adenosine monophosphate and cyclic guanosine monophosphate contents were determined. Results Compared with blank group, whole blood viscosity, plasma viscosity, plasma total cholesterol, triglyceride, low density lipoprotein cholesterin, thromboxane B2, thromboxane A2, cyclic guanosine monophosphate were significantly increased, 6-keto-prostaglandin F1α and prostacyclin were significantly decreased in model group, the differences were statistically significant (P ＜ 0.05). Compared with model group, the whole blood viscosity and plasma viscosity in Buyang Huanwu Decoction high-dose and low-dose groups were significantly decreased, and the plasma total cholesterol, triglyceride and low density lipoprotein cholesterin were significantly decreased, the plasma levels of thromboxane B2, thromboxane A2 and cyclic guanosine monophosphate in Buyang Huanwu Decoction high-dose and low-dose groups were significantly decreased, while the level of prostaglandin was significantly increased, with statistical significance (P ＜ 0.05). Compared with model group, the cyclic adenosine monophosphate in Buyang Huanwu Decoction low-dose group was significantly decreased, with statistical significance (P ＜ 0.05). Conclusion Buyang Huanwu Decoction can significantly improve the hemorheology and dyslipidemia of hyperlipidemia model rats, and can inhibit platelet aggregation, at the same time, it can prevent and treat the formation and development of hyperlipidemia and thrombosis.
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