Clinical effect of Compound Sea Buckthorn Seed Oil Suppository combined with Nifuratel Tablets in the treatment of senile bacterial vaginitis
ZHANG Lu1 DING Ding2 CHEN Bin3 ZHOU Qi1
1.Department of Gynaecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
2.Department of Gynaecology, Beijing New Century Women’s and Children’s Hospital, Beijing 100102, China;
3.Department of Gynaecology, Haidian Maternal and Child Health Care Hospital, Beijing 100080, China
Abstract：Objective To explore the effect of Compound Sea Buckthorn Seed Oil Suppository combined with Nifurtel Tablets in the treatment of senile bacterial vaginitis. Methods A total of 300 cases of senile bacterial vaginitis admitted to Beijing Obstetrics and Gynecology Hospital, Capital Medical University from March 2019 to March 2020 were included. They were divided into the study group and the control group according to the random number table method, with 150 cases in each group. The control group was treated with Nifuratel Tablets, and the study group was treated with Compound Sea Buckthorn Seed Oil Suppository on the basis of control group, both groups were treated for two weeks and the clinical efficacy of the two groups were observed. The improvement time of clinical symptoms, changes in vaginal environment, levels of inflammatory factors (interleukin-13 [IL-13], IL-6, tumor necrosis factor-α [TNF-α]) in vaginal lavage fluid and the occurrence of adverse reactions during treatment were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group (P < 0.05). The improvement time of leucorrhea, pruritus vulvae, pain, vaginal wall congestion, and edema in the study group were shorter than those in the control group (P < 0.05). After two weeks of treatment, the improvement of vaginal pH value and vaginal microflora density in the study group was better than those in the control group (P < 0.05). After two weeks of treatment, the levels of IL-13, IL-6, and TNF-α in vaginal lavage fluid of the two groups were lower than those before treatment, and the study group was lower than that the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Compound Sea Buckthorn Seed Oil Suppository combined with Nifuratel Tablets can improve the vaginal microecological environment of senile patients with bacterial vaginitis, reduce the vaginitis reaction, and have a good effect in the treatment of senile bacterial vaginitis.
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