Meta analysis of the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors
HU Mingmiao1 CHEN Mengjie2 LIANG Yuejuan2 WANG He2
1.Department of Gynecology, Wuming Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530199, China;
2.Department of Gynecology Tumor, Affiliated Tumor Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning 530021, China
Abstract：Objective To systematically evaluate the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors. Methods Literatures related to menstruation and fertility changes after fertility-sparing treatment for malignant ovarian germ cell tumors were searched in PubMed, EMbase, CNKI, Wanfang and other databases by computer. The search time was from the establishment of the database to January 2021. The method of combining subject words and key words was used to search. R3.6.1 software was used for data analysis. Results Finally, 13 articles involving 727 patients were included. Meta analysis results showed that, the complication rate of pregnancy was 88% (95%CI: 84%-92%) and the complication rate of normal menstruation was 90% (95%CI: 85%-95%) after fertility-sparing treatment for malignant ovarian germ cell tumor. Conclusion Fertility-sparing treatment for malignant ovarian germ cell tumors has little effect on ovarian function, and no lasting effect on menstruation and fertility function has been found at present.
胡明淼1 陈梦捷2 梁月娟2 王鹤2. 卵巢恶性生殖细胞肿瘤保留生育功能治疗后的内分泌及生育功能变化的meta分析[J]. 中国医药导报, 2021, 18(21): 96-100.
HU Mingmiao1 CHEN Mengjie2 LIANG Yuejuan2 WANG He2. Meta analysis of the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors. 中国医药导报, 2021, 18(21): 96-100.
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