Progress in basic research of surgically-induced brain injury
ZHENG Songyang1,2 LIU Tingting1,2 SUN Fangling1,2 ZHENG Wenrong1,2 ZHU Zixin1,2 ZHENG Ruifang3 XING Jianguo3 WANG Wen1,2,3,4
1.Department of Animal Laboratory, Xuanwu Hospital Capital Medical University, Beijing 100053, China;
2.Beijing Geriatrics Medical Research Center, Beijing 100053, China;
3.Xinjiang Uygur Autonomous Region Institute of Materia Medica, Xinjiang Uygur Autonomous Region, Urumqi 830002, China;
4.Beijing Institute of Brain Disorders, Beijing 100069, China
Abstract：Surgically-induced brain injury (SBI) refers to the healthy brain surrounding the surgical lesion suffers inevitable brain injury due to various factors such as the cutting and retraction of the brain tissue by surgical instruments, and intraoperative bleeding during the implementation of neurosurgery. This special brain injury is one of the important factors affecting the prognosis of surgery which will cause secondary lesions such as brain edema, cerebral hemorrhage and neuronal death. In recent years, basic research on SBI has made some progress. In this paper, the construction methods of SBI animal models, related molecular mechanisms and treatment methods are review, in order to provide the basis for exploring the pathogenesis of SBI and provide reference for the application and development of clinical treatment methods.
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