炎症因子及其抑制剂对脑缺血再灌注损伤作用的研究进展

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摘要脑缺血再灌注损伤（CIRI）是严重危害人类健康的复杂的病理生理过程，其中炎症反应是诱发CIRI的重要因素之一，大量炎症因子诱导神经元凋亡或坏死，并介导微血管功能障碍，继发脑出血或脑水肿，对机体造成不可逆的损伤。因此寻求针对CIRI的有效防护和治疗策略具有重要意义。本文介绍白细胞介素（IL）-1、肿瘤坏死因子-α和IL-6等炎症因子在CIRI过程中发挥的生理功能，列举近年将炎症因子作为靶点CIRI相关的药物和天然产物，为临床针对性地治疗CIRI提供依据。

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	任靓明田红旗

关键词 ：脑缺血, 再灌注损伤, 细胞因子, 炎症因子抑制剂

Abstract：Cerebral ischemia-reperfusion injury (CIRI) is a complex pathophysiological process and seriously endanger human health, in which inflammatory reaction is one of the important factors to induce CIRI. A large number of inflammatory factors effect neuronal apoptosis or necrosis, mediate microvascular dysfunction, and lead to cerebral hemorrhage or cerebral edema, causing irreversible damage to the body. Therefore, it is of great significance to seek effective prevention and treatment strategies for CIRI. This review introduces the physiological functions of inflammatory factors such as interleukin (IL)-1, tumor necrosis factor α and IL-6 in the process of CIRI, and lists the drugs and natural extracts related to inflammatory factors in recent years, so as to provide evidence for the clinical treatment of CIRI.

Key words： Brain ischemia Reperfusion injury Cytokines Anti-Inflammatory agents

基金资助:天津市科技计划项目（19YFZCSY00350、17ZXX YSY00090）；中国医学科学院放射医学研究所协助开发（委托）基金项目（IRM-QT2020045）。

通讯作者: 田红旗（1967.8-），男，博士，研究员；研究方向：放射医学。

作者简介: 任靓明（1996.10-），女，中国医学科学院北京协和医学院放射医学研究所2020级放射医学专业在读硕士研究生；研究方向：放射医学。

引用本文:

任靓明田红旗. 炎症因子及其抑制剂对脑缺血再灌注损伤作用的研究进展[J]. 中国医药导报, 2021, 18(12): 61-64.
REN Jingming TIAN Hongqi. Research progress of inflammatory factors and their inhibitors on cerebral ischemia-reperfusion injury. 中国医药导报, 2021, 18(12): 61-64.

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