Abstract：Nanoscience and nanotechnology are the research and application of tiny things. Nanotechnology is science, engineering and technology at the nanoscale of 1 to 100 nanometers. In recent years, nanotechnology has produced a huge and far-reaching influence in the research of various disciplines. Nanotechnology is widely used in dermatology, playing an important role in the diagnosis and treatment of many skin diseases, as well as dermatological surgery and cosmetology. For example, nanotechnology has improved the efficacy of drugs to treat common dermatological diseases such as psoriasis, androgen alopecia, and psoriasis. It helps the rapid diagnosis and localization of skin diseases. In dermatological surgery, nanoparticles can promote wound healing and serve as an effective substitute for suture lines. In terms of skin beauty, it is widely used in several topical skin care products, such as sunscreen. This paper introduces the concept of nanotechnology, summarizes the application of nanotechnology in the diagnosis and treatment of various skin diseases as well as dermatology surgery and cosmetology, and finally expounds the existing problems of nanotechnology.
韩冰玉 雷铁池. 纳米技术在皮肤科中的研究进展[J]. 中国医药导报, 2021, 18(12): 41-44,52.
HAN Bingyu LEI Tiechi . Research progress of nanotechnology in dermatology department. 中国医药导报, 2021, 18(12): 41-44,52.
[1] Pandey VN，Tiwari N，Pandey VS，et al. Targeted drug delivery and gene therapy through natural biodegradable nanostructures in pharmaceuticals[J]. Nanoarchitectonics in Biomedicine，2019：437-472.
[2] Nasimi P，Haidari M. Medical Use of Nanoparticles：Drug Delivery and Diagnosis Diseases[J]. International Journal of Green Nanotechnology，2013，1：1.
[3] Nasr M，Abdel-Hamid S，Moftah NH，et al. Jojoba Oil Soft Colloidal Nanocarrier of a Synthetic Retinoid： Preparation，Characterization and Clinical Efficacy in Psoriatic Patients [J]. Curr Drug Deliv，2017，14（3）：426-432.
[4] Roque LV，Dias IS，Cruz N，et al. Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia [J]. Skin Pharmacol Physiol，2017，30（4）：197-204.
[5] Wang F，Yang P，Choi JS，et al. Cross-Linked Fluorescent Supramolecular Nanoparticles for Intradermal Controlled Release of Antifungal Drug-A Therapeutic Approach for Onychomycosis [J]. ACS Nano，2018，12（7）：6851-6859.
[6] Papakostas D，Rancan F，Sterry W，et al. Nanoparticles in dermatology [J]. Arch Dermatol Res，2011，303（8）：533-550.
[7] Medina DX，Chung EP，Bowser R，et al. Lipid and polymer blended polyester nanoparticles loaded with adapalene for activation of retinoid signaling in the CNS following intravenous administration [J]. Journal of Drug Delivery Ence and Technology，2019，52：927-933.
[8] Rolland A，Wagner N，Chatelus A，et al. Site-specific drug delivery to pilosebaceous structures using polymeric microspheres [J]. Pharm Res，1993，10（12）：1738-1744.
[9] Ramkar S，Sah AK，Bhuwane N，et al. Nano-Lipidic Carriers as a Tool for Drug Targeting to the Pilosebaceous Units [J]. Current Pharmaceutical Design，2020，26（27）.
[10] Hia J，Nasir A. Photonanodermatology：the interface of photobiology，dermatology and nanotechnology [J]. Photodermatol Photoimmunol Photomed，2011，27（1）：2-9.
[11] Eden JG，Park SJ，Ostrom NP，et al. Recent advances in microcavity plasma devices and arrays： a versatile photonic platform[J]. Journal of Physics D Applied Physics，2005，38（11）：1644-1648.
[12] Mir M，Ali MN，Barakullah A，et al. Synthetic polymeric biomaterials for wound healing：a review[J]. Prog Biomater，2018，7（1）：1-21.
[13] Paredes D，Ortiz C，Torres R. Synthesis，characterization，and evaluation of antibacterial effect of Ag nanoparticles against Escherichia coli O157：H7 and methicillin-resistant Staphylococcus aureus （MRSA）[J]. Int J Nanomedicine，2014，9：1717-1729.
[14] Mallmann EJ，Cunha FA，Castro BN，et al. Antifungal activity of silver nanoparticles obtained by green synthesis [J]. Rev Inst Med Trop Sao Paulo，2015，57（2）：165-167.
[15] Liu J，Sonshine DA，Shervani S，et al. Controlled release of biologically active silver from nanosilver surfaces[J]. ACS Nano，2010，4（11）：6903-6913.
[16] Annabi N，Tamayol A，Shin SR，et al. Surgical Materials：Current Challenges and Nano-enabled Solutions [J]. Nano Today，2014，9（5）：574-589.
[17] Rose S，Prevoteau A，Elziere P，et al. Nanoparticle solutions as adhesives for gels and biological tissues[J]. Nature，2014，505（7483）：382-385.
[18] Shokri J. Nanocosmetics：benefits and risks[J]. Bioimpacts，2017，7（4）：207-208.
[19] Hussain A，Haque MW，Singh SK，et al. Optimized permeation enhancer for topical delivery of 5-fluorouracil-loaded elastic liposome using Design Expert：part Ⅱ[J]. Drug Deliv，2016，23（4）：1242-1253.
[20] Chen YY，Lu YH，Ma CH，et al. A novel elastic liposome for skin delivery of papain and its application on hypertrophic scar [J]. Biomed Pharmacother，2017，87：82-91.
[21] Jose J，Netto G. Role of solid lipid nanoparticles as photoprotective agents in cosmetics[J]. J Cosmet Dermatol，2018：18（1）：315-321.
[22] Netto MG，Jose J. Development，characterization，and evaluation of sunscreen cream containing solid lipid nanoparticles of silymarin [J]. J Cosmet Dermatol，2017， 17（16）：1073-1083.
[23] Marzuki NHC，Wahab RA，Hamid MA. An overview of nanoemulsion： concepts of development and cosmeceutical applications [J]. Biotechnology & Biotechnological Equipment，2019，33（1）：779-797.
[24] Okamoto T，Tomomasa S，Nakajima H. Preparation and Thermal Properties of Fatty Alcohol/Surfactant/Oil/Water Nanoemulsions and Their Cosmetic Applications[J]. J Oleo Sci，2016，65（1）：27-36.
[25] Pehlivan FE. Vitamin C：An Antioxidant Agent [M]. 2017： 23-25.
[26] Damiani E，Puglia C. Nanocarriers and Microcarriers for Enhancing the UV Protection of Sunscreens：An Overview [J]. J Pharm Sci，2019，108（12）：3769-3780.
[27] Morison WL，Wang ASQ. Sunscreens：safe and effective? [J].Med Lett Drugs Ther，1999，41（1052）：43-44.
[28] Nasir A. Nanodermatology：a glimpse of caution just beyond the horizon part Ⅱ[J]. Skin Therapy Lett，2010，15（9）：4-7.
[29] Nasrollahzadeh M，Sajadi SM. Risks of Nanotechnology to Human Life [J]. Interface Ence and Technology，2019.
[30] Kumar A，Gupta K，Dixit S，et al. A review on positive and negative impacts of nanotechnology in agriculture [J]. International Journal of Environmental Ence and Technology，2019，16（4）：2175-2184.
[31] Nel A，Xia T，Meng H，et al. Nanomaterial toxicity testing in the 21st century：use of a predictive toxicological approach and high-throughput screening[J]. Acc Chem Res，2013，46（3）：607-621.
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