progress of traditional Chinese and western medicine research on hyperemesis gravidarum
LIU Chengdong1 CHANG Hui1 LIU Deguang2 GONG Yi1 WANG Yu1 WU Yi1 ZUO Yanyan3 WU Xiaoke1▲
1.Department of Obstetrics and Gynecology, the First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China;
2.Department of Obstetrics and Gynecology, Daqing Hospital of Traditional Chinese Medicine, Heilongjiang Province, Daqing 163000, China;
3.Department of Obstetrics and Gynecology, Xianning Xian’an District Hospital of Traditional Chinese Medicine, Hubei Province, Xianning 437000, China
Abstract：The occurrence of hyperemesis gravidarum is related to genetic，physiological，psychological factors，and Helicobacter pylori is one of its independent risk factors. Western medicines Metoclopramide，Promethazine and Ondansetron can treat vomiting，but only vitamin B6 combined with Doxeramine are recommended as a first-line drug. Traditional Chinese medicine believes that pulsed chongqi up and reverse，stomach loss and fall are the main pathogenesis of hyperemesis gravidarum，which is often caused by deficiency of stomach，liver heat，and phlegm stagnation. Traditional Chinese medicine is mainly used to regulate qi, reduce adverse and stop vomiting. In severe cases, it is advisable to nourish qi and nourish yin. Acupoint stimulation can relieve some symptoms，and acupuncture treatment provides a new green direction that requires high-grade evidence-based medicine.
刘承东1 常惠1 刘德广2 宫艺1 王宇1 武祎1 左燕燕3 吴效科1▲. 妊娠剧吐的中西医研究进展[J]. 中国医药导报, 2021, 18(11): 37-40.
LIU Chengdong1 CHANG Hui1 LIU Deguang2 GONG Yi1 WANG Yu1 WU Yi1 ZUO Yanyan3 WU Xiaoke1▲. progress of traditional Chinese and western medicine research on hyperemesis gravidarum. 中国医药导报, 2021, 18(11): 37-40.
[1] Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No.189：Nausea And Vomiting Of Pregnancy [J]. Obstet Gynecol，2018，131（1）：e15-e30.
[2] Gadsby R，Barnie-Adshead AM，Jagger C. A prospective study of nausea and vomiting during pregnancy [J]. Br J Gen Pract，1993，43（371）：245-248.
[3] 中华医学会妇产科学分会产科学组.妊娠剧吐的诊断及临床处理专家共识（2015）[J].中华妇产科杂志，2015，50（11）：801-804.
[4] London V，Grube S，Sherer DM，et al. Hyperemesis gravidarum：a review of recent literature [J]. Pharmacology，2017，100（3/4）：161-171.
[5] Mitsuda N，Eitoku M，Maeda N，et al. Severity of nausea and vomiting in singleton and twin pregnancies in relation to fetal sex：the Japan environment and children’s study（JECS）[J]. J Epidemiol，2019，29（9）：340-346.
[6] 马宝璋.中医妇科学[M].2版.上海：上海科学技术出版社，2012：130-132.
[7] 谢幸，孔北华，段涛.妇产科学[M].9版.北京：人民卫生出版社，2018：81-82.
[8] Dekkers GWF，Broeren MAC，Truijens SEM，et al. Hormonal and psychological factors in nausea and vomiting during pregnancy [J]. Psychol Med，2020，50（2）：229-236.
[9] Fejzo MS，Sazonova OV，Sathirapongsasuti JF，et al. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum [J]. Nat Commun，2018，9（1）：1178.
[10] Fejzo MS，Arzy D，Tian R，et al. Evidence GDF15 plays a role in familial and recurrent hyperemesis gravidarum [J]. Geburtshilfe Frauenheilkd，2018，78（9）：866-870.
[11] Ng QX，Venkatanarayanan N，De Deyn MLZQ，et al. A meta-analysis of the association between Helicobacter pylori（H.pylori）infection and hyperemesis gravidarum [J]. Helicobacter，2018，23（1）：1-11.
[12] Grooten IJ，Den Hollander WJ，Roseboom TJ，et al. Helicobacter pylori infection：a predictor of vomiting severity in pregnancy and adverse birth outcome [J]. Am J Obstet Gynecol，2017，216（5）：512.e1-512.e9.
[13] McParlin C，O’Donnell A，Robson SC，et al. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy：a systematic review [J]. JAMA，2016，316（13）：1392-1401.
[14] Pasternak B，Svanstr?觟m H，M?覬lgaard-Nielsen D，et al. Metoclopramide in pregnancy and risk of major congenital malformations and fetal death [J]. JAMA，2013，310（15）：1601-1611.
[15] Tan PC，Khine PP，Vallikkannu N，et al. Promethazine compared with metoclopramide for hyperemesis gravidarum：a randomized controlled trial [J]. Obstet Gynecol，2010，115（5）：975-981.
[16] Ritchie HE，Huss IB，Webster WS. The effect of anti-emetic drugs on rat embryonic heart activity [J]. Reprod Toxicol，2019，87：140-145.
[17] Danielsson B，Webster WS，Ritchie HE. Ondansetron and teratogenicity in rats：evidence for a mechanism mediated via embryonic hERG blockade [J]. Reprod Toxicol，2018， 81：237-245.
[18] Lemon LS，Bodnar LM，Garrard W，et al. Ondansetron use in the first trimester of pregnancy and the risk of neonatal ventricular septal defect [J]. Int J Epidemiol，2020， 49（2）：648-656.
[19] Parker SE，Van Bennekom C，Anderka M，et al. Ondansetron for treatment of nausea and vomiting of pregnancy and the risk of specific birth defects [J]. Obstet Gynecol，2018， 132（2）：385-394.
[20] Huybrechts KF，Hernández-Díaz S，Straub L，et al. Association of maternal first-trimester ondansetron use with cardiac malformations and oral clefts in offspring [J]. JAMA，2018，320（23）：2429-2437.
[21] 胡荣魁，谈勇.夏桂成国医大师调治妊娠诸疾经验探赜[J].江苏中医药，2015，47（12）：1-4.
[22] 韩艳华，王雪莲，张雪芝，等.韩氏妇科诊治妊娠恶阻之经验浅析[J].辽宁中医杂志，2017，44（2）：252-253.
[23] 王冬盈，邓咏诗，郜洁.岭南罗氏妇科治疗妊娠恶阻的用药经验总结[J].中药材，2019，42（3）：683-685.
[24] Allais G，Chiarle G，Sinigaglia S，et al. Acupuncture treatment of migraine，nausea，and vomiting in pregnancy [J]. Neurol Sci，2019，40（Suppl 1）：213-215.
[25] Adlan AS，Chooi KY，Mat Adenan NA. Acupressure as adjuvant treatment for the inpatient management of nausea and vomiting in early pregnancy：a double-blind randomized controlled trial [J]. J Obstet Gynaecol Res，2017， 43（4）：662-668.
[26] Tara F，Bahrami-Taghanaki H，Amini Ghalandarabad M，et al. The effect of acupressure on the severity of nausea，vomiting，and retching in pregnant women：a randomized controlled trial [J]. Complement Med Res，2020，27（4）：252-259.
[27] Negarandeh R，Eghbali M，Janani L，et al. Auriculotherapy as a means of managing nausea and vomiting in pregnancy：a double-blind randomized controlled clinical trial [J]. Complement Ther Clin Pract，2020，40：101177.
[28] 冯欣，许忠波，叶琳，等.内关穴注射维生素B1治疗妊娠剧吐效果的meta分析及试验序贯分析[J].中国医药导报，2020，17（9）：87-90，102.
[29] 刘格利，刘小利，张素宁，等.妊娠剧吐患者心理影响因素及心理治疗效果分析[J].国际精神病学杂志，2015， 42（6）：98-101.
[30] 何亚丽.心理干预加音乐疗法在妊娠剧吐患者中的应用及效果观察[J].中南医学科学杂志，2015，43（4）：476-478.
[31] Anh NH，Kim SJ，Long NP，et al. Ginger on human health：a comprehensive systematic review of 109 randomized controlled trials [J]. Nutrients，2020，12（1）：157.
[32] Hu Y，Amoah AN，Zhang H，et al. Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy：a meta-analysis [J]. J Matern Fetal Neonatal Med，2020，14：1-10.
[33] Sharifzadeh F，Kashanian M，Koohpayehzadeh J，et al. A comparison between the effects of ginger，pyridoxine（vitamin B6）and placebo for the treatment of the first trimester nausea and vomiting of pregnancy（NVP）[J]. J Matern Fetal Neonatal Med，2018，31（19）：2509-2514.
[34] 欧阳振波，尹倩，全松，等.中、美、加、英妊娠期恶心呕吐及妊娠剧吐诊治指南的解读[J].现代妇产科进展，2017， 26（11）：875-877.
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