Research progress of IgA-mediated mucosal immunity and regulation of intestinal flora in the onset of childhood asthma
HOU Shuting1,2 LU Yuan3 ZHAO Xia1,2
1.Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province, Nanjing 210029, China;
2.Jiangsu Key Laboratory of Pediatric Respiratory Disease (Tradition Chinese Medicine), Jiangsu Province, Nanjing 210023, China;
3.Department of Traditional Chinese Medicine, Children’s Hospital of Soochow University, Jiangsu Province, Nanjing, 215000 China
Abstract：Asthma is a common chronic respiratory disease in children, which seriously affects the physical and mental health and quality of life of children. The airways and intestines of children with asthma have varying degrees of damage to the mucosal epithelial cells, and immunoglobulin A (IgA) is the main antibody secreted by mucosal immunity, which can limit the colonization of the intestinal flora and maintain the balance of the intestinal flora and protect the epithelial cell layer Integrity, thereby preventing asthma and improving its prognosis. In addition, Chinese medicine has cloud “exteiror-interior relationship between lung and large intestine”, and “lung and bowel combined treatment” is a common method of clinical treatment of asthma, IgA may be a bridge between the lung and large intestine. This paper summarized the literature from the perspective of the effect of IgA in mucosal immunity on children’s asthma, in order to provide new ideas for the mechanism research of children’s asthma, provide new targets for clinical treatment, and provide scientific theoretical support for “exteiror-interior relationship between lung and large intestine”.
候淑婷1,2 陆远3 赵霞1,2. IgA介导黏膜免疫及调节肠道菌群参与儿童哮喘发病的研究进展[J]. 中国医药导报, 2021, 18(10): 31-34.
HOU Shuting1,2 LU Yuan3 ZHAO Xia1,2. Research progress of IgA-mediated mucosal immunity and regulation of intestinal flora in the onset of childhood asthma. 中国医药导报, 2021, 18(10): 31-34.
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