Effect of Tegafur, Gimeracil and Oteracil Porassium Capsules combined with Oxaliplatin on the expression of gastrin and survivin antibodies in serum of patients with advanced gastric cancer
LYU Xiujuan CHEN Xin WANG Yan
Department of Geriatric Oncology, the 4th People′s Hospital of Shenyang City, Liaoning Province, Shenyang 110031, China
Abstract：Objective To investigate the clinical efficacy of Tegafur, Gimeracil and Oteracil Porassium Capsules combined with Oxaliplatin in the treatment of advanced gastric cancer and its effect on the expression of gastrin (GAS) and survivin antibodies in serum. Methods A total of 100 patients with advanced gastric cancer treated in the 4th People′s Hospital of Shenyang City from January 2015 to June 2017 were divided into observation group and control group by random envelope method, with 50 cases in each group. The control group was treated with Capecitabine combined with Oxaliplatin, and the observation group was treated with Tegafur, Gimeracil and Oteracil Porassium Capsules combined with Oxaliplatin. Both groups were treated for 4 cycles. After treatment, the short-term clinical efficacy was assessed, and adverse reactions and quality of life were evaluated. Blood GAS and survivin antibody levels were detected before and after treatment. Results The short-term total effective rate of treatment in the observation group was significantly higher than that in the control group(P ＜ 0.05). The total improvement rate of the quality of life in the observation group after treatment was significantly higher than that of the control group (P ＜ 0.05). GAS and survivin of patients in the two groups significantly decreased after treatment (P ＜ 0.05). The GAS and survivin antibodies in the blood of the patients were significantly lower than those in the control group (P ＜ 0.05), and the incidence of nausea, vomiting and diarrhea in the observation group was significantly lower than that of the control group (P ＜ 0.05). Conclusion The combination of Tegafur, Gimeracil and Oteracil Porassium Capsules and Oxaliplatin can effectively improve the clinical efficacy and reduce the levels of serum GAS and survivin antibody in patients with advanced gastric cancer. It is of high clinical value.
吕秀娟 陈新 王艳. 替吉奥联合奥沙利铂治疗对中晚期胃癌患者血清胃泌素、survivin抗体表达的影响[J]. 中国医药导报, 2019, 16(11): 97-100.
LYU Xiujuan CHEN Xin WANG Yan. Effect of Tegafur, Gimeracil and Oteracil Porassium Capsules combined with Oxaliplatin on the expression of gastrin and survivin antibodies in serum of patients with advanced gastric cancer. 中国医药导报, 2019, 16(11): 97-100.
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2019, Vol. 16 
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