Network meta-analysis of Osimertinib combination therapy for advanced non-small cell lung cancer
SANG Bulin1 HUANG Huiyuan2 WANG Xurao2 DONG Lixian2 XU Rong2 FAN Yuxin2 FENG Jin2 HE Jianchang2
1.School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Yunnan Province, Kunming 650500, China; 2.Clinical Pharmacology Research Center, Yunnan Provincial Hospital of Traditional Chinese Medicine, Yunnan Province, Kunming 650103, China
Abstract：Objective To evaluate the efficacy of Osimertinib (OSI) combination therapy in the treatment of advanced non-small cell lung cancer (NSCLC) by network meta-analysis. Methods Cochrane Library, PubMed, CNKI, Wanfang Data, and China Biology Medicine Disc were searched for randomized controlled trials on OSI combination therapy of advanced non-small cell lung cancer from the inception to September 2022. Information extraction and quality evaluation were performed on the included studies. Stata 15.0 and Review Manager 5.3 software were used for network meta-analysis. Results A total of 25 literatures were included, involving 2 374 patients. The intervention measures included OSI alone and OSI combined with first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), standard treatment (first-generation EGFR-TKI + platinum), Shenyi Capsules, Valmenin Capsules, Yiqi Yangyin Prescription, Bevacizumab, and chemotherapy, and the control measures included OSI, first-generation EGFR-TKI, standard treatment, chemotherapy, and chemotherapy combined with Bevacizumab. The top three interventions in the surface under the cumulative ranking curve (SUCRA) of objective response rate were OSI + Yiqi Yangyin Prescription (85.0%), OSI + Beizumab (72.4%), OSI+ standard treatment (71.6%), and OSI+ Shengyi Capsules (71.6%). The top three interventions in SUCRA in disease control rate were OSI+ Bevacizumab (88.7%), OSI+ Valmenin Capsules (86.2%), and OSI+ Yiqi Yangyin Prescription (76.0%). Conclusion In the treatment of advanced non-small cell lung cancer, the combination of OSI, Yiqi Yangyin Prescription, and Bevacizumab may be the best choice in the future.
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2023, Vol. 20 
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