Predictive efficacy of serum macrophage inflammatory protein-3α com-bined with receptor interacting protein kinase 3 levels for the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure
LI Pinqing1 YAO Yu2 DING Kai1 XUE Chenqi1 QIU Jie1
1.The First Department of Tumor and Vascular Disease Intervention, Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine the Second Hospital of Nanjing, Jiangsu Province, Nanjing 210003, China; 2.the Second Department of Tumor and Vascular Disease Intervention, Nanjing Hospital Affiliated to Nanjing University of Traditional Chinese Medicine the Second Hospital of Nanjing, Jiangsu Province, Nanjing 210003, China
Abstract：Objective To investigate the predictive efficacy of serum macrophage inflammatory protein-3α (MIP-3α) combined with receptor interacting protein kinase 3 (RIPK3) on the short-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF). Methods A total of 246 patients with HBV-ACLF admitted to the Second Hospital of Nanjing from February 2021 to July 2022 were selected. The serum levels of MIP-3α and RIPK3 were detected. According to the survival situation within 30 days, the patients were divided into the death group (73 cases) and the survival group (173 cases). The clinical data of the two groups were compared, and the factors affecting the short-term prognosis of patients with HBV-ACLF and the predictive value of MIP-3α and RIPK3 for the prognosis of patients with HBV-ACLF were analyzed. Results The serum albumin level in the death group was lower than that in the survival group, the international normalized ratio, model for end-stage liver disease (MELD) score, the proportion of complicated encephalopathy, and the serum total bilirubin, MIP-3α, and RIPK3 levels were higher than those in the survival group (P＜0.05). MELD score (OR=3.347, 95%CI: 1.844-6.073), and serum MIP-3α (OR=2.079, 95%CI: 1.307-3.309), RIPK3 (OR=2.004, 95%CI: 1.312-3.060) were influential factors for short-term prognosis of HBV-ACLF patients (P＜0.05). MELD score combined with serum MIP-3α and RIPK3 predicted the prognosis of HBV-ACLF patients with higher area under the receiver operator charcateristic curve than the area under the curve predicted by the three alone (P＜0.05). Conclusion Serum MIP-3α and RIPK3 levels are elevated in HBV-ACLF patients, and are associated with short-term death. Combined analysis of MELD score and serum MIP-3α, RIPK3 helped to indicate the prognosis of patients.
2023, Vol. 20 
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