Efficacy and safety of atorvastatin plus low-molecular-weight dextran volume expansion in the treatment of acute cerebral infarction
FENG Xiaoli1 LI Jun1 JING Jing2 BIAN Keyu1▲
1.Department of Neurology, Wujin Hospital of Traditional Chinese Medicine, Jiangsu Province, Changzhou 213000, China; 2.Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100000, China
Abstract：Objective To investigate the efficacy and safety of atorvastatin plus low-molecular-weight dextran volume expansion in the treatment of acute cerebral infarction. Methods A total of 160 cases of acute cerebral infarction admitted to Wujin Hospital of Traditional Chinese Medicine in Changzhou from February 2018 to February 2022 were selected and they were divided into study group and control group by random number table method, with 80 cases in each group. The control group received routine treatment and Atorvastatin Calcium treatment, while the study group received low-molecular-weight dextran volume expansion treatment. After one week of treatment, patients of both groups were evaluated for efficacy, serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were compared between the two groups, and activities of daily life (ADL), Barthel index (BI), and Montreal cognitive assessment (MOCA) scores of cognitive function were compared between the two groups. Results The clinical efficacy of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). After one week of treatment, the levels of TNF-α and IL-6 in two groups were lower than those before treatment, and the study group was lower than control group, the differences were statistically significant (P＜0.05). After one week of treatment, MOCA, ADL, and BI scores in two groups were higher than those before treatment, and the study group was higher than control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P＞0.05). Conclusion The intensive treatment of low-molecular-weight dextran volume expansion for acute cerebral infarction is helpful to promote the rapid recovery of patients, reduce the level of inflammation, improve cognitive function, improve the quality of life, and reduce the incidence of adverse reactions.
2023, Vol. 20 
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