Abstract：Objective To explore the clinical effect of Acyclovir combined with Transfer Factor Oral Solution in the treatment of children with infectious mononucleosis (IM). Methods A total of 84 children with IM admitted to Nanjing Lishui District People’s Hospital from January 2017 to April 2022 were selected as the study subjects. They were divided into the control group and study group according to the randem number table method, with 42 cases in each group. The control group were treated with Acyclovir intravenously, and the study group was treated with Acyclovir combined with Transfer Factor Oral Liquid. One week after treatment, the clinical effective rate, the regression time of angina pectoris, the regression time of cervical lymphadenopathy, the regression time of fever, the levels of CD3+, CD4+, CD4+/CD8+, serum immunoglobulin G (IgG), IgA, IgM and the incidence of adverse reactions during treatment were compared between the two groups. Results The curative effect of the study group was higher than that of the control group (P＜0.05). The regression time of angina pectoris, the regression time of cervical lymphadenopathy and fever in the study group were shorter than those in the control group (P＜0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+, IgG, IgA and IgM were higher than those before treatment, the study group was higher than the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Acyclovir Transfer Factor Oral Liquid combined with in the treatment of children with infectious mononucleosis is more helpful to improve immune function, enhance clinical efficacy and good safety.
孙鹏玲 傅彬 孙瑶. 阿昔洛韦联合转移因子口服液治疗传染性单核细胞增多症患儿的临床效果[J]. 中国医药导报, 2023, 20(21): 113-116.
SUN Pengling FU Bin SUN Yao. Clinical effect of Acyclovir combined with Transfer Factor Oral Liquid in the treatment of children with infectious mononucleosis. 中国医药导报, 2023, 20(21): 113-116.
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