Analysis on the correlation between serum liver enzymes and the incidence of type 2 diabetes mellitus in middle-aged and elderly residents in Lanzhou
DING Yulu1 ZHANG Di1 YANG Mengdi1 WANG Yujie1 SUN Linnan1 HE Fengying1 ZHEN Donghu2
1.The First Clinical Medical College, Lanzhou University, Gansu Province, Lanzhou 730030, China;
2.Department of Endocrinology, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730030, China
Abstract：Objective To investigate the relationship between alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (GGT) and type 2 diabetes mellitus (T2DM) in middle-aged and elderly residents in Lanzhou. Methods In 2011, a cluster of 5 135 residents aged 40 to 75 years old from three communities in Lanzhou were randomly sampled, and 3 832 residents meeting the exclusion criteria were eventually included. They were divided into four groups according to ALT, AST, and GGT quartile (group Q1 to Q4). Non-interventional follow-up ≥three years of T2DM events. Logistic regression analysis of the correlation between serum liver enzymes and T2DM. The predictive value of serum liver enzymes for T2DM was analyzed by receiver operating characteristic (ROC) curve. Results Non-interventional follow-up ≥three years, the incidence of T2DM was 6.99% (268/3 832). The number of fasting blood glucose, 2-hour post-meal blood glucose, glycosylated hemoglobin, ALT, GGT, triglyceride, and rate of fatty liver in T2DM group were higher than that in non-T2DM group, and the differences were statistically significant (P＜0.05); high density lipoprotein cholesterol (HDL-C) was lower than that in non-T2DM group, and the difference was statistically significant (P＜0.05). The incidence of T2DM in ALT group Q4 was higher than that in ALT group Q1 and Q2, and the differences were statistically significant (P＜0.05). The incidence of T2DM in GGT group Q3 and Q4 was higher than that in GGT group Q1 and Q2, and the differences were statistically significant (P＜0.05). Logistic regression analysis showed that elevated ALT and GGT were independent risk factors for T2DM (OR＞1, P＜0.05). ROC curve showed that ALT predicted the critical value, area under the curve, sensitivity and specificity of T2DM to be 18.5 U/L, 0.593, 0.519, and 0.634, while GGT to be 20.5 U/L, 0.614, 0.616, and 0.572, respectively. Conclusion The elevation of ALT and GGT in middle-aged and elderly residents in Lanzhou may be associated with the onset of T2DM.
丁雨露1 张迪1 杨孟迪1 王玉洁1 孙琳楠1 何风英1 甄东户2. 兰州市中老年居民的血清肝酶与2型糖尿病发病的相关性分析[J]. 中国医药导报, 2023, 20(19): 30-34.
DING Yulu1 ZHANG Di1 YANG Mengdi1 WANG Yujie1 SUN Linnan1 HE Fengying1 ZHEN Donghu2. Analysis on the correlation between serum liver enzymes and the incidence of type 2 diabetes mellitus in middle-aged and elderly residents in Lanzhou. 中国医药导报, 2023, 20(19): 30-34.
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