饮食模式和肠道菌群与肥胖关系的研究进展

doi:10.20047/j.issn1673-7210.2023.16.13

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摘要肥胖是一种复杂的、多因素的且在很大程度上可预防的慢性代谢性疾病，目前已成为严重的健康负担。肥胖与多种代谢相关疾病的患病风险增加及发生不良预后有关。肥胖的发生及发展受遗传、环境、饮食、生活行为方式等众多因素的影响，其中，饮食模式和肠道菌群发挥关键作用。不同的饮食模式对肠道菌群水平带来不同的结局，可进一步影响肥胖的发生及发展轨迹。本文以饮食模式及肠道菌群的变化作为探讨对象，分析二者在改善肥胖中的作用方面作一综述。

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	阿依木古丽·艾尼　　靳瑾

关键词 ：肥胖, 肠道菌群, 饮食模式, 能量代谢

Abstract：Obesity is a complex, multifactorial, and largely preventable chronic metabolic disease, which has now become a serious health burden. Obesity is associated with an increased risk of multiple metabolic-related diseases and adverse prognosis. The occurrence and development of obesity are influenced by genetics, environment, diet, lifestyle and other factors, among which, dietary pattern and intestinal flora play a key role. Different dietary patterns bring different outcomes to the level of intestinal flora, which can further affect the occurrence and development trajectory of obesity. In this paper, dietary pattern and intestinal flora changes as the object of discussion, analysis of the two in improving the role of obesity.

Key words： Obesity Intestinal flora Dietary pattern Energy metabolism

基金资助:新疆维吾尔自治区自然科学基金项目（2022D01C318）。

通讯作者: 靳瑾（1982.7-），女，医学博士，副教授；研究方向：糖尿病及其并发症，代谢性疾病及肠道菌群。

作者简介: 阿依木古丽·艾尼（1995.5-），女，新疆医科大学第五临床医学院2020级内科学（内分泌方向）在读硕士研究生，主要从事肥胖与相关因素研究。

引用本文:

阿依木古丽·艾尼　　靳瑾. 饮食模式和肠道菌群与肥胖关系的研究进展[J]. 中国医药导报, 2023, 20(16): 62-65.
Ayimuguli Aini　JIN Jin. Research progress on the relationship between dietary patterns, intestinal flora and obesity. 中国医药导报, 2023, 20(16): 62-65.

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[1] Natsis M，Antza C，Doundoulakis I. Hypertension in obesity：novel insights [J]. Curr Hypertens Rev，2020，16（1）：30-36.
[2] Saltiel AR，Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease [J]. J Clin Invest，2017，127（1）：1-4.
[3] Bendor CD，Bardugo A，Pinhas-Hamiel O. Cardiovascular morbidity，diabetes and cancer risk among children and adolescents with severe obesity [J]. Cardiovasc Diabetol，2020， 19（1）：79.
[4] Oussaada SM，van Galen KA，Cooiman MI，et al. The pathogenesis of obesity [J]. Metabolism，2019，92：26-36.
[5] Thursby E，Juge N. Introduction to the human gut microbiota [J]. Biochem J，2017，474（11）：1823-1836.
[6] Stojanov S，Kreft S. Gut microbiota and the metabolism of phytoestrogens [J]. Rev Bras Farmacogn，2020，30（2）：145- 154.
[7] Cheng HY，Ning MX，Chen DK，et al. Interactions Between the Gut Microbiota and the Host Innate Immune Response Against Pathogens [J]. Front Immunol，2019，10：607.
[8] Turpin W，Espin-Garcia O，Xu W，et al. Association of host genome with intestinal microbial composition in a large healthy cohort [J]. Nat Genet，2016，48（11）：1413-1417.
[9] 刘莹，谭寅凤，张金月，等.超重肥胖和正常体重人群肠道菌群的差异分析[J].中国临床研究，2022，35（1）：21-24.
[10] Wu JY，Wang K，Wang XM，et al. The role of the gut microbiome and its metabolites in metabolic diseases [J]. Protein Cell，2021，12（5）：360-373.
[11] Kimura I，Ozawa K，Inoue D，et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short- chain fatty acid receptor GPR43 [J]. Nat Commun，2013，4：1829.
[12] Rowland I，Gibson G，Heinken A，et al. Gut microbiota functions：metabolism of nutrients and other food components [J]. Eur J Nutr，2018，57（1）：1-24.
[13] Holmes ZC，Silverman JD，Dressman HK，et al. Short-chain fatty acid production by gut microbiota from children with obesity is linked to bacterial community composition and prebiotic choice [J]. mBio，2020，11（4）：e914-e920.
[14] Cani PD. Human gut microbiome：Hopes，threats and prom- ises [J]. Gut，2018，67（9）：1716-1725.
[15] Mozaffarian D. Dietary and Policy Priorities for Cardiovascular Disease，Diabetes，and Obesity：A Comprehensive Review [J]. Circulation，2016，133（2）：187-225.
[16] Bisanz JE，Upadhyay V，Turnbaugh JA，et al. Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet [J]. Cell Host Microbe，2019， 26（2）：265-272.
[17] Beam A，Clinger E，Lei H. Effect of Diet and Dietary Components on the Composition of the Gut Microbiota [J]. Nutrients，2021，13（8）：2795.
[18] Atakan MMM，Koar NS，Guzel Y，et al. The Role of Exercise，Diet，and Cytokines in Preventing Obesity and Improving Adipose Tissue [J]. Nutrients，2021，13（5）：1459.
[19] Lazar V，Ditu LM，Pircalabioru GG，et al. Gut Microbiota，Host Organism，and Diet Trialogue in Diabetes and Obesity [J]. Front Nutr，2019，6：21.
[20] Zmora N，Suez J，Elinav E. You are what you eat：diet，hea- lth and the gut microbiota [J]. Nat Rev Gastroenterol Hepatol，2019，16（1）：35-56.
[21] Singh RK，Chang HW，Yan D，et al. Influence of diet on the gut microbiome and implications for human health [J]. J Transl Med，2017，15（1）：73.
[22] Agus A，Denizot J，Thévenot J，et al. Western diet induces a shift in microbiota composition enhancing susceptibility to Adherent-Invasive E. coli infection and intestinal inflammation [J]. Sci Rep，2016，6：19032.
[23] 吴亚，殷峻.生酮饮食调控肠道菌群在疾病治疗中的研究进展[J].上海交通大学学报：医学版，2022，42（4）：545-550.
[24] Olson CA，Vuong HE，Yano JM，et al. The Gut Microbiota Mediates the Anti-Seizure Effects of the Ketogenic Diet [J]. Cell，2018，173（7）：1728-1741.
[25] Ma D，Wang AC，Parikh I，et al. Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice [J]. Sci Rep，2018，8（1）：6670.
[26] Nagpal R，Neth BJ，Wang SH，et al. Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer’s disease markers in subjects with mild cognitive impairment [J]. EBioMedicine，2019，47：529-542.
[27] Qi YA，Alexander M，Newman JC，et al. Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells [J]. Cell，2020，181（6）：1263-1275.
[28] Zhu HY，Bi DX，Zhang YZ，et al. Ketogenic diet for human diseases：the underlying mechanisms and potential for clinical implementations [J]. Signal Transduct Target Ther，2022， 7（1）：11.
[29] Rychter AM，Ratajczak AE，Zawada A，et al. Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity [J]. Nutrients，2020，12（3）：814.
[30] Filippis FD，Pellegrini N，Vannini L，et al. High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome [J]. Gut，2016，65（11）：1812-1821.
[31] Mitsou EK，Kakali A，Antonopoulou S，et al. Adherence to the Mediterranean diet is associated with the gut microbiota pattern and gastrointestinal characteristics in an adult population [J]. Br J Nutr，2017，117（12）：1645-1655.
[32] Izaskun GM，Marta SR，Cristina A，et al. Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population [J]. Front Microbiol，2018，9：890.
[33] Rohr MW，Narasimhulu CA，Rudeski-Rohr TA，et al. Negative Effects of a High-Fat Diet on Intestinal Permeability：A Review [J]. Advances Nutr，2020，11（1）：77-91.
[34] Lewis JD，Chen EZ，Baldassano RN，et al. Inflammation，Antibiotics，and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease [J]. Cell Host Microbe，2015，18（4）：489-500.
[35] Luan H，Wang X，Cai Z. Mass spectrometry-based meta- bolomics：Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders [J]. Mass Spectrom Rev，2019，38（1）：22-33.
[36] Régnier M，Hul MV，Knauf C，et al. Gut microbiome，endocrine control of gut barrier function and metabolic diseases [J]. J Endocrinol，2021，248（2）：R67-R82.
[37] Li HY，Zhou DD，Gan RY，et al. Effects and Mechanisms of Probiotics，Prebiotics，Synbiotics，and Postbiotics on Metabolic Diseases Targeting Gut Microbiota：A Narrative Review [J]. Nutrients，2021，13（9）：3211.
[38] Antonella G，Valentina T，Fatima C，et al. Rebuilding the Gut Microbiota Ecosystem [J]. Int J Environ Res Public Health，2018，15（8）：1679.
[39] Rinninella E，Raoul P，Cintoni M，et al. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age，Environment，Diet，and Diseases [J]. Microo- rganisms，2019，7（1）：14.