Analysis of medication rule in different age stages of focal adenomyosis based on data mining
DING Nan1 LIU Shuang2 SHI Wei3 LIU Zhiyong3 ZHAO Ruoxi4
1.Yueyang Clinical Medical College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
2.the First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China;
3.Department of Gynecology, the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250014, China; 4.College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Shandong Province, Jinan 250355, China
Abstract：Objective To analyze the medication rule of focal adenomyopathy (AM) patients of different ages in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, so as to expand the idea of conservative and phased treatment of AM. Methods Data of focal AM patients in the outpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2012 to December 2017 were collected. Frequency analysis, multi-scale backbone network analysis, and other data mining methods were used to summarize the population distribution, high-frequency drug use, efficacy ratio, and core prescriptions of each age group. Results The age of onset was highest in patients aged 30-49 years. Core prescriptions for different age groups were obtained. The core prescriptions of 20-＜30 years old were stir-frying with vinegar Corydalis Rhizoma, stir-frying with vinegar Cyperi Rhizoma, Typhae Pollen, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Rubra, Paeoniae Radix Alba, stir-frying with salt Foeniculi Fructus; the core prescriptions of 30-＜40 years old were stir-frying with vinegar Cyperi Rhizoma, stir-frying with vinegar Corydalis Rhizoma, Typhae Pollen, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Paeoniae Radix Alba, Leonuri Herba, Forsythiae Fructus, stir-frying with salt Foeniculi Fructus; the core prescriptions of 40-＜50 years old were stir-frying with vinegar Cyperi Rhizoma, stir-frying with vinegar Corydalis Rhizoma, Leonuri Herba, Chuanxiong Rhizoma, Paeoniae Radix Alba, Typhae Pollen, Ostreae Concha, Angelicae Sinensis Radix, Codonopsis Radix; the core prescriptions of 50-55 years old were Ostreae Concha, Typhae Pollen, Codonopsis Radix, Rehmanniae Radix, stir-frying Astragali Radix, Phellodendri Chinensis Cortex, Ecliptae Herba, stir-frying with wine Ligustri Lucidi Fructus, Anemarrhenae Rhizoma, stir-frying with vinegar Cyperi Rhizoma. Conclusion The onset age of focal AM patients tends to be younger. The treatment of focal AM should be based on activating blood circulation to dissipate blood stasis, regulating qi and relieving pain, and according to the pathogenesis differences of different age groups, with the treatment of warming interior and dispersing cold, clearing heat and detoxifying, replenishing qi and nourishing blood, tonifying kidney and nourishing yin, removing blood stasis and stopping bleeding, etc., to expand the conservative and phased treatment of the disease.
丁楠１ 刘双2 师伟3▲ 刘志勇3 赵若曦4. 基于数据挖掘的局灶性子宫腺肌病不同年龄段用药规律分析[J]. 中国医药导报, 2023, 20(14): 132-136.
DING Nan1 LIU Shuang2 SHI Wei3 LIU Zhiyong3 ZHAO Ruoxi4. Analysis of medication rule in different age stages of focal adenomyosis based on data mining. 中国医药导报, 2023, 20(14): 132-136.
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