Preoperative diagnostic value of two-dimensional ultrasound combined with BRAF gene detection for benign and malignant thyroid nodules undefined by FNAC#br#
CHEN Jiejie YUAN Yingying▲ HE Lili
Department of Ultrasound, Huaian First People’s Hospital, Jiangsu Province, Huaian 223300, China
Abstract：Objective To explore the preoperative diagnostic value of two-dimensional ultrasound combined with BRAF gene detection for benign and malignant thyroid nodules undefined by fine-needle aspiration cytology (FNAC). Methods A total of 119 patients with thyroid nodules admitted to Huaian First People’s Hospital from June 2019 to December 2021 were selected as the study subjects. Two-dimensional ultrasound and BRAF gene detection were performed before the operation. The pathological results after the operation were taken as the gold standard, the diagnostic value of two-dimensional ultrasound combined with BRAF gene detection for benign and malignant thyroid nodules was analyzed, Kappa test was performed for the diagnostic results. Results Pathological results showed that 87 benign thyroid nodules and 32 malignant thyroid nodules. The accuracy, sensitivity, and specificity of two-dimensional ultrasound in the diagnosis of benign and malignant thyroid nodules were 81.51%, 90.62%, and 78.16% respectively; Kappa test results showed that there was general consistency between two-dimensional ultrasound and pathological findings in the evaluation of benign and malignant thyroid nodules (Kappa=0.594, P＜0.01). The accuracy, sensitivity, and specificity of BRAF gene detection in the diagnosis of benign and malignant thyroid nodules were 89.92%, 93.75%, and 88.51% respectively; Kappa test results showed that BRAF gene detection and pathologic results were generally consistent in evaluating benign and malignant thyroid nodules (Kappa=0.637, P＜0.01). The accuracy, sensitivity, and specificity of two-dimensional ultrasound combined with BRAF gene detection were 83.19%, 96.86%, and 78.16%, respectively; Kappa test results showed that there was a good consistency between two-dimensional ultrasound combined with BRAF gene detection and pathological findings in the evaluation of benign and malignant thyroid nodules (Kappa=0.762, P＜0.01). Conclusion Two-dimensional ultrasound combined with BRAF gene detection can improve the sensitivity of preoperative diagnosis and has important significance in preoperative diagnosis of benign and malignant thyroid nodules.
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