Abstract：Objective To investigate the clinical effect of Chaihu Guizhi Longgu Muli Decoction combined with tiaoshen kaiyu acupuncture on post stroke depression. Methods A total of 126 patients with post stroke depression admitted to Heilongjiang College of Traditional Chinese Medicine from June 2021 to June 2022 were selected and they were divided into three groups by random number table method, with 42 cases in each group. The decoction group was treated with routine therapy+Chaihu Guizhi Longgu Muli Decoction orally, the acupuncture group was treated with routine therapy+tiaoshen kaiyu acupuncture, and the combined group was treated with routine therapy+Chaihu Guizhi Longgu Muli Decoction orally+tiaoshen kaiyu acupuncture, with 15 days as a course of treatment, and three courses of treatment. The symptom score, depression score, serological index level, clinical efficacy, and adverse reaction rate of patients were evaluated. Results After treatment, the scores of symptoms and depression in the three groups decreased, and those in the combined group were lower than those in the decoction group and acupuncture group (P＜0.05); after treatment, serum levels of homocysteine, microtubule-associated protein, and ubiquitin carboxy-terminal hydrolase L1 in three groups were decreased, and those in the combined group were lower than those in the decoction group and acupuncture group (P＜0.05). The clinical efficacy of combination group was better than that of decoction group and acupuncture group (P＜0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P＞0.05). Conclusion Chaihu Guizhi Longgu Muli Decoction combined with tiaoshen kaiyu acupuncture has a significant effect on post stroke depression, can improve the clinical symptoms of patients, inhibit brain damage, and has good safety.
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