Abstract：Objective To investigate the effect of Pregabalin combined with Lipoic acid on patients with diabetic painful neuropathy. Methods A total of 86 patients with diabetic painful neuropathy admitted to the Seventh People’s Hospital of Chongqing from July 2019 to December 2020 were selected and divided into control group (43 cases) and experimental group (43 cases) according to random number table method. Both groups received conventional treatment, the control group was treated with Lipoic acid combined with Gabapentin, and the experimental group was treated with Lipoic acid combined with Pregabalin, the course of treatment was four weeks. The efficacy, numerical rating scale (NRS) score, Michigan diabetic neuropathy score (MDNS), and nerve conduction velocity before and after treatment were compared between the two groups. The occurrence of adverse drug reaction (ADR) was recorded in the two groups. Results After treatment, the therapeutic effect of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). After treatment, NRS scores and MDNS in two groups were lower than those before treatment, and experimental groups were lower than those of control group, and the differences were statistically significant (P＜0.05). After treatment, the motor nerve conduction velocity and sensory nerve conduction velocity of median nerve and common peroneal nerve in two groups were higher than before treatment, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of ADR between the two groups (P＞0.05). Conclusion The treatment effect of Pregabalin combined with Lipoic acid is better than that of Lipoic acid combined with Gabapentine in patients with diabetic painful neuropathy, and the incidence of ADR is lower.
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