Effect of Compound Cistanche Yizhi Capsules on mild and moderate Alzheimer’s disease with deficiency of liver and kidney and phlegm-stasis blocking collaterals
HONG Liang SUN Ping YANG Yanfu FANG Wujie
Department of Neurology, Lu’an Hospital of Traditional Chinese Medicine, Anhui Province, Lu’an 237000, China
Abstract：Objective To explore the effect of Compound Cistanche Yizhi Capsules on mild and moderate Alzheimer’s disease (AD) with deficiency of liver and kidney and phlegm-stasis blocking collaterals. Methods A total of 120 patients with mild and moderate AD with deficiency of liver and kidney and phlegm-stasis blocking collaterals admitted to Lu’an Hospital of Traditional Chinese Medicine from May 2020 to March 2021 were selected, they were divided into control group and study group by random number table method, with 60 cases in each group. The control group was treated with Donepezil Hydrochloride Tablets, while the study group was treated with Compound Cistanche Yizhi Capsules on the basis of the control group, the course of treatment was six months. The clinical efficacy of the two groups after treatment was compared, the cognitive function, self-care ability, estradiol (E2), and hypoxia-inducible factor 1-α (HIF1-α) levels were compared between the two groups before and after treatment, and the adverse reactions during the treatment were recorded in the two groups. Results The clinical efficacy of the study group was better than that of the control group (P＜0.05). After treatment, the mini-mental state scale and Barthel index scores in the two groups were higher than those before treatment, and the study group were higher than those in the control group (P＜0.05); after treatment, E2 in the two groups increased, while HIF1-α decreased, and E2 in the study group was higher than that in the control group, and HIF1-α was lower than that in the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Compound Cistanche Yizhi Capsules in the treatment of mild and moderate AD with deficiency of liver and kidney and phlegm-stasis blocking collaterals can significantly improve patients’ cognitive function and self-care ability, with definite curative effect and good safety.
洪亮 孙平 杨言府 方无杰. 复方苁蓉益智胶囊治疗肝肾亏虚兼痰瘀阻络型轻中度阿尔茨海默病的效果[J]. 中国医药导报, 2023, 20(8): 87-90.
HONG Liang SUN Ping YANG Yanfu FANG Wujie. Effect of Compound Cistanche Yizhi Capsules on mild and moderate Alzheimer’s disease with deficiency of liver and kidney and phlegm-stasis blocking collaterals. 中国医药导报, 2023, 20(8): 87-90.
京公网安备 11010502046598号