Abstract:Saccharum Alhagi is a kind of traditional Uyghur ethnic medicine, which is a sugar granule secreted and condensed from the branches and leaves of the leguminous plant Alhagi Sparsifolia Shap. The use of Saccharum Alhagi in Chinese medicine has a long history. Compendium of Materia Medica records that Saccharum Alhagi has the functions of nourishing and strengthening, balancing body fluids, regulating endocrine and astringent intestinal pain, expectorating cough, and so on. Saccharum Alhagi contains a large number of polysaccharides, oligosaccharides, flavonoids, volatile oil, amino acids, trace elements, and other chemical components. With the continuous study of its pharmacological activity, it has been found that the extract of Saccharum Alhagi has the activities of immune regulation, liver and kidney protection, bacteriostatic, antioxidant, hypoglycemic, double regulation of intestinal smooth muscle, and so on. In this paper, the research progress of chemical constituents and pharmacological activities of Saccharum Alhagi in recent years is reviewed in order to provide new ideas and references for further development and clinical research of Saccharum Alhagi.
陈盈盈 宋建忠 李杰 陈章浩 常军民. 刺糖化学成分及其生物活性研究进展[J]. 中国医药导报, 2023, 20(7): 42-45,58.
CHEN Yingying SONG Jianzhong LI Jie CHEN Zhanghao CHANG Junmin. Research progress on chemical constituents and pharmacological activities of Saccharum Alhagi. 中国医药导报, 2023, 20(7): 42-45,58.
[1] Wei F,Yang X,Pang K,et al. Traditional Uses,Chemistry,Pharmacology,Toxicology and Quality Control of Alhagi sparsifolia Shap.:A Review [J]. Front Pharmacol,2021,12:761811.
[2] Umair M,Altaf M,Bussmann RW,et al. Ethnomedicinal uses of the local flora in Chenab riverine area,Punjab province Pakistan [J]. J Ethnobiol Ethnomed,2019,15(1):7.
[3] 宋建忠,陈盈盈,杨婧,等.人工神经网络-遗传算法优化刺糖低聚糖提取工艺的研究[J].中国食品添加剂,2022, 33(6):1-7.
[4] 曲真真.刺糖多糖对小鼠TLR4靶点的免疫活性作用机制研究[D].乌鲁木齐:新疆医科大学,2019.
[5] 贾月梅,石明辉,夏提古丽·阿不利孜,等.骆驼刺化学成分及药理活性研究进展[J].中国野生植物资源,2022,41(1):47-51,71.
[6] 米克热木·沙衣布扎提,蒋志惠,吾买尔江·牙合甫,等.传统维药骆驼刺刺糖有效成分及药理作用研究进展[J].中药材,2016,39(10):2397-2399.
[7] Chang T,Li H,Lv H,et al. Extraction,Physicochemical Properties,Anti-Aging,and Antioxidant Activities of Polysaccharides from Industrial Hemp Residues [J]. Molecules,2022, 27(18):5746.
[8] Peng Y,Zhao L,Hu K,et al. Anti-Fatigue Effects of Lycium barbarum Polysaccharide and Effervescent Tablets by Regulating Oxidative Stress and Energy Metabolism in Rats [J]. Int J Mol Sci,2022,23(18):10920.
[9] Liu N,Chen M,Song J,et al. Effects of Auricularia auricula Polysaccharides on Gut Microbiota Composition in Type 2 Diabetic Mice [J]. Molecules,2022,27(18):6061.
[10] Liu G,Feng S,Yan J,et al. Antidiabetic potential of polysaccharides from Brasenia schreberi regulating insulin signaling pathway and gut microbiota in type 2 diabetic mice [J]. Curr Res Food Sci,2022,5:1465-1474.
[11] Nataraj A,Govindan S,Ramani P,et al. Antioxidant,Anti-Tumour,and Anticoagulant Activities of Polysaccharide from Calocybe indica(APK2)[J]. Antioxidants(Basel),2022,11(9):1694.
[12] Wang X,Zhang S,Shang H,et al. Evaluation of the antiviral effect of four plant polysaccharides against duck circovirus [J]. Res Vet Sci,2022,152:446-457.
[13] Ren G,Xu L,Zhao J,et al. Antiviral Activity of Crude Polysaccharide Derived from Seaweed against IHNV and IPNV In Vitro [J]. Viruses,2022,14(9):2080.
[14] Jiang Y,Shang Z,Lv X,et al. Structure elucidation and antitumor activity of a water soluble polysaccharide from Hemicentrotus pulcherrimus [J]. Carbohydr Polym,2022, 292:119718.
[15] 菅丽君.刺糖多糖的分离纯化和结构分析[D].乌鲁木齐:新疆医科大学,2012.
[16] 菅丽君,常军民,李改茹.刺糖多糖的分离纯化与结构分析[J].中国药学杂志,2013,48(7):505-508.
[17] 常军民,李改茹,郑杰,等.刺糖多糖结构表征[J].中国新药杂志,2016,25(24):2826-2830.
[18] 程煜凤,李改茹,常军民.新疆维药刺糖化学成分研究[J].中国测试,2014,40(2):53-55.
[19] Sun Q,Liu Q,Zhou X,et al. Flavonoids regulate tumor-associated macrophages-From structure-activity relationship to clinical potential(Review)[J]. Pharmacol Res,2022, 184:106419.
[20] 程煜凤,常军民,李改茹,等.维药刺糖挥发油的GC-MS分析[J].中国新药杂志,2010,19(6):531-533.
[21] 郭明鑫,吴霞,冯毅凡.刺糖总黄酮的提取工艺优化及其成分的快速分析[J].中药新药与临床药理,2020,31(9):1110-1116.
[22] Li G,Xiang Y,Zhao J,et al. Saccharum Alhagi polysaccharide-1 and -2 promote the immunocompetence of RAW264.7 macrophages in vitro [J]. Exp Ther Med,2018,15(4):3556-3562.
[23] Cai G,Yang Y,Gu P,et al. The secretion of sIgA and dendritic cells activation in the intestinal of cyclophosphamide-induced immunosuppressed mice are regulated by Alhagi honey polysaccharides [J]. Phytomedicine,2022, 103:154232.
[24] Wusiman A,Xu S,Ni H,et al. Immunomodulatory effects of Alhagi honey polysaccharides encapsulated into PLGA nanoparticles [J]. Carbohydr Polym,2019,211:217-226.
[25] 韩曾姣.刺糖多糖对巨噬细胞RAW264.7的免疫调节及信号通路的研究[D].乌鲁木齐:新疆医科大学,2017.
[26] Zhang L,Zhang F,Xiao Y,et al. The nuclear receptor REV- ERBα regulates CYP2E1 expression and acetaminophen hepatotoxicity [J]. Xenobiotica,2022:31-38.
[27] Jiang Z,Jiang X,Li C,et al. Development of an IgY Antibody-Based Immunoassay for the Screening of the CYP2E1 Inhibitor/Enhancer from Herbal Medicines [J]. Front Pharmacol,2016,7:502.
[28] 艾力·艾尔肯,库尔班江·麦麦提敏,蒋志惠,等.刺糖对对乙酰氨基酚诱导的肝损伤的保护作用[J].中国畜牧兽医,2017,44(7):2185-2190.
[29] 米克热木·沙衣布扎提,海如拉·马木提,姚琛.刺糖对庆大霉素致小鼠肾损伤保护作用的初步研究[J].中国畜牧兽医,2013,40(3):230-233.
[30] 吾买尔江·牙合甫,艾力·艾尔肯,迪丽努尔,等.维药刺糖对小鼠急性肾损伤的保护作用初探[C]//中国畜牧兽医学会动物生理生化学分会.全国动物生理生化第七届全国代表大会暨第十三次学术交流会论文摘要汇编,2014:2.
[31] 张倩,孟新源,张明君,等.维吾尔药材刺糖的体外抑菌效果[J].中国民族民间医药,2015,24(18):5-6.
[32] MutailIfu P,Nuerxiati R,Lu C,et al. Extraction,purification,and characterization of polysaccharides from Alhagi pseudoalhagi with antioxidant and hypoglycemic activities [J]. Process Biochem,2022,121:339-348.
[33] 赵津,李改茹,郑杰,等.维药刺糖抗氧化活性多糖筛选研究[J].新疆医科大学学报,2015,38(12):1479- 1481.
[34] 向阳,贺家勇,郑杰,等.刺糖粗多糖对糖尿病大鼠降糖及抗氧化功能的实验研究[J].时珍国医国药,2017,28(6):1281-1284.
[35] 曹雯丽,贾舒安,陈阳,等.刺糖对小鼠肠推进和离体小肠平滑肌运动的影响[J].新疆农业大学学报,2011,34(3):193-196.
[36] Cai G,Wusiman A,Gu P,et al. Supplementation of Alhagi honey polysaccharides contributes to the improvement of the intestinal immunity regulating the structure of intestinal flora in mice [J]. Food Funct,2021,12(20):9693-9707.
[37] Cai G,Wu Y,Wusiman A,et al. Alhagi honey polysaccharides attenuate intestinal injury and immune suppression in cyclophosphamide-induced mice [J]. Food Funct,2021,12(15):6863-6877.