Research progress on the relationship between human immunodeficiency virus infection and vaginal microorganisms
ZHANG Shuangxia LIU Zhaohui
Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing Maternal and Child Health Care Hospital, Beijing 100031, China
Abstract：Heterosexual transmission of human immunodeficiency virus (HIV) through the genital mucosa is the most common route of infection in women, but the immunobiological factors contributing to HIV susceptibility remain unclear. Vaginal microorganisms play a crucial role in HIV infection, and a better understanding of the relationship between vaginal microorganisms and HIV infection is essential to effectively control the epidemic. Sexually transmitted infections and bacterial vaginosis caused by Neisseria gonorrhoeae, Trichomonas vaginalis, Chlamydia trachomatis, and others can cause confusion in the vaginal microorganisms, which increases HIV susceptibility, and human papillomavirus infection rates among HIV-infected women are significantly higher. This paper reviews the current relationship between HIV infection and vaginal microorganisms in women and reviews recent findings on vaginal microorganisms and HIV susceptibility.
张双霞 刘朝晖. 人类免疫缺陷病毒感染与阴道微生物关系的研究进展[J]. 中国医药导报, 2022, 19(34): 43-45,56.
ZHANG Shuangxia LIU Zhaohui. Research progress on the relationship between human immunodeficiency virus infection and vaginal microorganisms. 中国医药导报, 2022, 19(34): 43-45,56.
[1] UNAIDS. Global HIV&AIDS statistics——FACT SHEET. 2021 [EB/OL]. https://www.unaids.org/en/resources/fact-sheet.
[2] Ravel J，Gajer P，Abdo Z，et al. Vaginal microbiome of reproductive-age women [J]. Proc Natl Acad Sci U S A，2011， 108（S1）：4680-4687.
[3] Alisoltani A，Manhanzva MT，Potgieter M，et al. Microbial function and genital inflammation in young South African women at high risk of HIV infection [J]. Microbiome，2020，8（1）：165.
[4] 张展，刘朝晖.混合性阴道炎与阴道微生态[J].中国实用妇科与产科杂志，2020，36（2）：185-189.
[5] Armstrong E，Kaul R. Beyond bacterial vaginosis：vaginal lactobacilli and HIV risk [J]. Microbiome，2021，9（1）：239.
[6] Torcia MG. Interplay among Vaginal Microbiome，Immune Response and Sexually Transmitted Viral Infections [J]. Int J Mol Sci，2019，20（2）：266.
[7] Hoang T，Toler E，De Long K，et al. The cervicovaginal mucus barrier to HIV-1 is diminished in bacterial vaginosis [J]. PLoS Pathog，2020，16（1）：e1008236.
[8] Dabee S，Barnabas SL，Lennard KS，et al. Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection [J]. PLoS One，2019，14（4）：e0213975.
[9] Cherne MD，Cole AL，Newberry L，et al. Matrix Metalloproteinases Expressed in Response to Bacterial Vaginosis Disrupt the Endocervical Epithelium，Increasing Transmigration of HIV [J]. Infect immune，2020，88（4）：e00041-e00020.
[10] Dwyer-Lindgren L，Cork MA，Sligar A，et al. Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017 [J]. Nature，2019，570（7760）：189-193.
[11] McClelland RS，Lingappa JR，Srinivasan S，et al. Key Vaginal Bacteria Associated with Increased Risk of HIV Acquisition in African Women：A Nested Case-Control Study [J]. Lancet Infect Dis，2018，18（5）：554-564.
[12] Gosmann C，Anahtar MN，Handley SA，et al. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women [J]. Immunity，2017，46（1）：29-37.
[13] McKinnon LR，Liebenberg LJ，Yende-Zuma N，et al. Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women [J]. Nat Med，2018，24（4）：491-496.
[14] Nicol MR，Eneh P，Nakalega R，et al. Depot Medroxyprogesterone Acetate and the Vaginal Microbiome as Modifiers of Tenofovir Diphosphate and Lamivudine Triphosphate Concentrations in the Female Genital Tract of Ugandan Women：Implications for Tenofovir Disoproxil Fumarate/ Lamivudine in Preexposure Prophylaxis [J]. Clin Infect Dis，2020，70（8）：1717-1724.
[15] Liebenberg LJP，McKinnon LR，Yende-Zuma N，et al. HPV infection and the genital cytokine milieu in women at high risk of HIV acquisition [J]. Nat Commun，2019，10（1）：5227.
[16] Shannon B，Yi TJ，Perusini S，et al. Association of HPV infection and clearance with cervicovaginal immunology and the vaginal microbiota [J]. Mucosal Immunol，2017，10（5）：1310-1319.
[17] Duan R，Zhang H，Wu A，et al. Prevalence and risk factors for anogenital HPV infection and neoplasia among women living with HIV in China [J]. Sex Transm Infect，2022，98（4）：247-254.
[18] Ermel A，Tonui P，Titus M，et al. A cross-sectional analysis of factors associated with detection of oncogenic human papillomavirus in human immunodeficiency virus-infected and uninfected Kenyan women [J]. BMC Infect Dis，2019， 19（1）：352.
[19] Carter KA，Srinivasan S，Fiedler TL，et al. Vaginal Bacteria and Risk of Incident and Persistent Infection With High-Risk Subtypes of Human Papillomavirus：A Cohort Study Among Kenyan Women [J]. Sex Transm Dis，2021， 48（7）：499-507.
[20] Shannon B，Gajer P，Yi TJ，et al. Distinct Effects of the Cervicovaginal Microbiota and Herpes Simplex Type 2 Infection on Female Genital Tract Immunology [J]. J Infect Dis，2017，215（9）：1366-1375.
[21] Crisci E，Svanberg C，Ellegard R，et al. HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells [J]. Front Immunol，2019，10：2889.
[22] Looker KJ，Magaret AS，May MT，et al. First estimates of the global and regional incidence of neonatal herpes infection [J]. Lancet Glob Health，2017，5（3）：e300-e309.
[23] Looker KJ，Welton NJ，Sabin KM，et al. Global and regional estimates of the contribution of herpes simplex virus type 2 infection to HIV incidence：a population attributable fraction analysis using published epidemiological data [J]. Lancet Infect Dis，2020，20（2）：240-249.
[24] Torrone EA，Morrison CS，Chen PL，et al. Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa：An individual participant data meta-analysis of 18 HIV prevention studies [J]. PLoS Med，2018，15（2）：e1002511.
[25] Gudisa R，Goyal K，Gupta P，et al. Localized and Systemic Immune Response in Human Reproductive Tract [J]. Front Cell Infect Microbiol，2021，11：649893.
[26] Barker EK，Malekinejad M，Merai R，et al. Risk of HIV acquisition among high-risk heterosexuals with nonviral sexually transmitted infections：A systematic review and meta- analysis [J]. Sex Transm Dis，2022，49（6）：383-397.
[27] Ding J，Rapista A，Teleshova N，et al. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation [J]. J Immunol，2010，184（6）：2814-2824.
[28] Wong WF，Chambers JP，Gupta R，et al. Chlamydia and Its Many Ways of Escaping the Host Immune System [J]. J Pathog，2019 ，2019：8604958.
[29] Masha SC，Cools P，Sanders EJ，et al. Trichomonas vaginalis and HIV infection acquisition：a systematic review and meta-analysis [J]. Sex Trans Infect，2019，95（1）：36-42.
[30] Van Gerwen OT，Muzny CA. Recent advances in the epidemiology，diagnosis，and management of Trichomonas vaginalis infection [J]. F1000Res，2019，8：F1000 Faculty Rev-1666.
[31] 中华医学会感染病学分会艾滋病丙型肝炎学组，中国疾病预防控制中心.中国艾滋病诊疗指南（2018版）[J].新发传染病电子杂志，2019，4（2）：65-84.
[32] 王佩芝，梁慧超，龙滨.HIV感染合并阴道感染性疾病临床回顾性分析[J].中国妇产科临床杂志，2020，21（1）：10-12.
[33] 闵秋思.124例HIV女性患者阴道微生态特征分析[D].昆明：昆明医科大学，2020.
[34] Elwood C，Albert A，Mcclymonts E，et al. Different and diverse anaerobic microbiota were seen in women living with HIV with unsuppressed HIV viral load and in women with recurrent bacterial vaginosis：a cohort study [J]. BJOG，2020，127（2）：250-259.
京公网安备 11010502046598号