Clinical characteristics and influencing factor of prognosis of human immuno-deficiency virus combined with disseminated Mycobacterium avium complex patients in parts of northern China
WEI Huaying1* WANG Lijing2* CUI Xiao1 YANG Yang1 CHEN Xue1 MA Ping3 ZHANG Yulin1
1.Department of Respiratory and Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China;
2.Department of Infectious Disease, Shijiazhuang Fifth Hospital, Hebei Province, Shijiazhuang 050024, China;
3.the Second Department of Infectious Disease, Tianjin Second People’s Hospital, Tianjin 300192, China
Abstract：Objective To investigate the clinical characteristics and influencing factor of prognosis factors of human immunodeficiency virus (HIV) with disseminated Mycobacterium avium complex (DMAC) patients in some areas of northern China. Methods The clinical data of HIV with DMAC patients who were hospitalized in Beijing Youan Hospital, Capital Medical University, Tianjin Second People’s Hospital, and Shijiazhuang Fifth Hospital from January 2014 to January 2020 were collected, and the information of HIV with disseminated Mycobacterium tuberculosis (DMTB) patients who were hospitalized in these three hospitals at the same time were also collected. The clinical characteristics of HIV with DMAC patients were compared, and further follow-up was conducted to analyze the influencing factor of prognosis. Results The levels of alkaline phosphatase and γ-glutamyl transpeptidase, the incidence of hepatomegaly, the incidence of splenomegaly, and the initiation rate of anti-retroviral therapy (ART) in HIV with DMAC patients were higher than those in HIV with DMTB patients, the incidence of pleural effusion was lower than that of HIV combined with DMTB infection, and the differences were statistically significant (P ＜ 0.05). The proportion of non-initiated ART, the level of CRP, and HIV viral load in patients who died after HIV with DMAC were higher than those in survival patients, and the level of HGB was lower than that in survival patients, and the differences were statistically significant (P ＜ 0.05). ART initiation, hemoglobin, and C-reactive protein were prognostic factors of HIV with DMAC patients (P ＜ 0.05). Conclusion The clinical and imaging features are helpful for the preliminary differentiation between HIV with DMAC patients and HIV with DMTB patients. ART is of great significance for the prognosis of HIV with DMAC patients.
魏华英1* 王立静2* 崔晓1 杨洋1 陈雪1 马萍3 张玉林1. 中国北方部分地区人类免疫缺陷病毒合并播散性鸟分枝杆菌复合群感染者的临床特征及预后影响因素[J]. 中国医药导报, 2022, 19(28): 102-105,110.
WEI Huaying1* WANG Lijing2* CUI Xiao1 YANG Yang1 CHEN Xue1 MA Ping3 ZHANG Yulin1. Clinical characteristics and influencing factor of prognosis of human immuno-deficiency virus combined with disseminated Mycobacterium avium complex patients in parts of northern China. 中国医药导报, 2022, 19(28): 102-105,110.
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