Abstract：The gaseous signaling molecules nitric oxide, carbon monoxide, and hydrogen sulfide have anti-inflammatory, antioxidant, and anti-apoptotic properties. In addition, by regulating TGF-β/Smads, PI3K/AKT, Nrf2/HO-1, and nuclear factor-κB signaling pathways, it can inhibit the proliferation and activation of fibroblasts, reduce collagen deposition and epithelial-mesenchymal transition, thereby reducing the proliferation and activation of fibroblasts, and improving idiopathic pulmonary fibrosis. This article reviews the anti-pulmonary fibrosis effects of three gas signal molecules and their molecular mechanisms, and opens up a new therapeutic approach for the use of gas signal molecules and their donors in the treatment of pulmonary fibrosis in the future.
李傲寒 白羽 王茜茜 陈颖卿. 气体信号分子对特发性肺纤维化的作用机制研究进展[J]. 中国医药导报, 2022, 19(28): 41-45.
LI Aohan BAI Yu WANG Qianqian CHEN Yingqing. Research progress on the mechanism of action of gas signal molecules on idiopathic pulmonary fibrosis. 中国医药导报, 2022, 19(28): 41-45.
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