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| Analyzing gene expression profiles in ventricular remodeling after myocardial infarction via bioinformatics methods |
| NIU Xiaowei1,2 ZHANG Jingjing3 PENG Yu2,4 BAI Ming2,4 ZHANG Zheng2,4 |
1.The First Clinical Medical College, Lanzhou University, Gansu Province, Lanzhou 730000, China;
2.Gansu Key Laboratory of cardiovascular disease, Gansu Province, Lanzhou 730000, China;
3.Baiyin Second People′s Hospital, Gansu Province, Baiyin 730900, China;
4.The Heart Center, the First Hospital of Lanzhou University, Gansu Province, Lanzhou 730000, China |
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Abstract Objective To identify the molecular mechanisms underlying ventricular remodeling after myocardial infarction using bioinformatics methods. Methods Microarray data about ventricular remodeling after myocardial infarction were searched from GEO database. Results The array data of GSE47495 were obtained. A total of 611 DEG were identified. Gene ontology analysis showed that the DEG significantly enriched in biological processes, molecular function, and cell component. Pathway analysis showed the DEGs were involved in signaling pathways. The top 3 hub genes, Acox1, Anxa1, and F13a1 were identified from protein-protein interaction network. Results from drug screening indicated that palm oil and curcumin may regulate the above genes. Conclusion During post infarction ventricular remodeling, the identified DEG are mainly enriched in metabolism, extracellular matrix, inflammation, and coagulation. The hub genes, Acox1, Anxa1, and F13a1 provid potential targets for treatment of ventricular remodeling. Palm oil and curcumin may improve the ventricular remodeling through the regulation of these genes.
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