五生酊外治配合WHO三阶梯镇痛方案治疗轻中度癌性疼痛的效果

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Abstract Objective To observe the clinical effect of traditional Chinese medicine Wusheng Tincture combined with WHO "three stage" analgesic regimen in the treatment of mild and moderate cancer pain. Methods One hundred and twenty-six patients with cancer pain treated in Department of Oncology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from September 2015 to February 2017 were selected as research objects, and they were randomly divided into the treatment group (65 cases) and control group (61 cases). According to numerical rating scale, in the treatment group, mild pain patients accounted for 50.8% (33/65), moderate pain patients accounted for 49.2% (32/65), while in the control group, mild pain patients accounted for 50.8% (31/61), moderate pain patients accounted for 49.2% (30/61). The control group was taken WHO "three stage" analgesic regimen and the pain site was treated with placebo tincture; the treatment group was treated with Wusheng Tincture on the pain site on basis of control group. The two groups were treated for 7 days as one course. NRS was used to assess the pain level of the patients, the brief pain inventory (BPI) was used to evaluate the quality of life, the clinical effects and adverse reactions between the two groups were observed. The data was analyzed and processed by SPSS 18.0. Results A total of 120 patients completed the study (6 patients were excluded for the external use of cold stimulation). After treatment, the NRS scores in the two groups were all lower than those before treatment (P ＜ 0.01), and the NRS score of the treatment group was significantly lower than that of the control group, the difference was highly statistically significant (P ＜ 0.01). After treatment, the scores of BPI in the two groups were all significantly lower than those before treatment (P ＜ 0.05), and the BPI score of the treatment group was significantly lower than that of the control group, the difference was highly statistically significant (P ＜ 0.01). The BPI score of patients with mild pain in the treatment group after treatment was significantly lower than that of control group (P ＜ 0.05), while there was no significant difference of the BPI score between the patients with moderate pain in treatment group and control group (P ＞ 0.05). There was no statistically significant difference of total effective rate between the two groups (P ＞ 0.05). The incidence of constipation with Ⅳ degree in the treatment group was significantly lower than that in the control group (P ＜ 0.01), and the overall incidence of adverse reactions in the treatment group was significantly lower than that in the control group (P ＜ 0.05). Conclusion Compared with patients with moderate pain, external use of Wusheng Tincture has better effects for the analgesic efficacy and improvement of quality of life.

Key words： Cancer pain Wusheng Tincture External use "Three stage" analgesia regimen

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	HE Wenfeng1 YANG Xiaobing1 XU Lei2 ZHANG Liling3 LI Qiuping1 BI Jiayi1 LI Qiuxia4 DENG Hong1

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HE Wenfeng1 YANG Xiaobing1 XU Lei2 ZHANG Liling3 LI Qiuping1 BI Jiayi1 LI Qiuxia4 DENG Hong1. Clinical effect of Wusheng Tincture combined with WHO "three stage" analgesic regimen in treating patients with mild and moderate cancer pain[J]. 中国医药导报, 2017, 14(30): 25-29.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2017/V14/I30/25

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