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| Clinical effect of Levodopa and Benserazide Hydrochloride combined with Entacapone in the treatment of Parkinson disease |
| WANG Zhiqing YAN Yan▲ |
| Department of Pharmacy, Nanjing Brain Hospital, Jiangsu Province, Nanjing 210029, China |
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Abstract Objective To investigate the effect of Levodopa and Benserazide Hydrochloride combined with Entacapone in the treatment of Parkinson disease. Methods One hundred and two patients with Parkinson disease treated in Nanjing Brain Hospital (“our hospital” for short) from January 2014 to June 2016 were selected and randomly divided into combined group and monotherapy group, with 51 cases in each group. Another 51 healthy persons taken body examination in our hospital were selected as control group. The monotherapy group was given conventional Levodopa and Benserazide Hydrochloride, on basis of which, the combined group was added with Entacapone, both groups were treated for 12 weeks. The efficacy and the scores of unified Parkinson disease rating scale Ⅲ (UPDRSⅢ) and activities of daily living (ADL) before and after treatment in the two groups were compared. The motor evoked potential (MEP) of the two groups was detected before and after treatment, including relaxed motor threshold (RMT), cortical latency (CL), cortical silent period (CSP); the levels of plasma homocysteine (Hcy), serum superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) of the two groups were observed before and after treatment, which were compared with control group; the peak concentration of Levodopa and average daily dosage of Levodopa and Benserazide Hydrochloride of the two groups were compared; the conditions of adverse reactions of the two groups were recorded after treatment for half years. Results After treatment, the scores of UPDRSⅢ, ADL in combined group were lower than those before treatment, while RMT, CL, CSR were increased compared with those before treatment (P ＜ 0.05); after treatment, the scores of UPDRSⅢ in monotherapy group were lower than those before treatment, while CL, CSR were increased (P ＜ 0.05); after treatment, the scores of UPDRSⅢ, ADL in combined group were lower than those of monotherapy group, while RMT, CL, CSR were all higher than those of control group (P ＜ 0.05). After treatment, the plasma Hcy in monotherapy group was higher than those of combined group and control group (P ＜ 0.05), while combined group was higher than control group (P ＜ 0.05); the levels of SOD, GSH and GSH-Px in monotherapy group were all lower than those of combined group and control group (P ＜ 0.05), while combined group was lower than control group (P ＜ 0.05). The peak concentration of LD in combined group was higher than that of monotherapy group, while average daily dosage of Levodopa and Benserazide Hydrochloride was lower than that of monotherapy group, the differences were all statistically significant (P ＜ 0.05). At the same time, the total effective rate in combined group (84.3%) was higher than that of monotherapy group (62.7%) (P ＜ 0.05), but the incidence of adverse reactions between combined group (19.6%) and monotherapy group (23.5%) had no statistically significant difference (P ＞ 0.05). Conclusion Levodopa and Benserazide Hydrochloride combined with Entacapone in the treatment of Parkinson disease can make the bioavailability of LD in vivo higher, inhibit the abnormal increase of plasma Hcy, relieve the damage of oxygen free radicals at the same time, with significant effects, which is worthy of promotion.
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