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| Study on HPV subtype distribution in Dali region of yunnan province |
| ZHAO Lixian BI Lei YANG Xitong WANG Guangming HE Ju |
| Department of Pathology, the First Affiliated Hospital of Dali University, Yunnan Province, Dali 671000, China |
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Abstract Objective To understand the characteristics of human papillomavirus (HPV) infection in Dali region of yunnan province by analysis of the infection of HPV in the population of physical examination. Methods From January 2013 to November 2015, 2912 female patients received in Medical Examination Center of the First Affiliated Hospital of Dali University were selected, and divided into 13 type group (1587 cases) and 21 type group (1325 cases) according to the random number table. 13 type group was used to 13 types of high risk HPV detection by real-time PCR, 21 type group was used to type 21 HPV subtype detection by molecular hybridization, and the results of two kinds of detection techniques are compared and analyzed. Results In the 13 type group, a total of 206 cases of positive patients with 13 high-risk subtypes including HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68 were detected,with a positive rate of 12.98%(206/1587). In the 21 type group, 246 cases were infected with HPV, with the positive rate of 18.57% (246/1325). A total of 20 subtypes except low-risk HPV43 were detected. The most common HPV genotypes were HPV16 with the positive rate of 29.67%(73/246). Second, HPV52 subtype 21.14% (52/246) in 20 types of HPV subtypes. Conclusion The infection of HPV in Dali region, Yunnan Province, has heterogeneity. The detection rate of the two detection methods was not different, and the selection of the detection method should be selected according to the clinical needs.
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