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| Effect of Tangbi Washout Formula in the treatment of peripheral vascular disease in patients with type 2 diabetes mellitus |
| LU Qiyun1 CHEN Benjian2 LIN Yuping2 |
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510405, China;
2.Guangdong Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510120, China |
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Abstract Objective To observe the effect of Tangbi Washout Formula in the treatment of peripheral vascular disease in patients with type 2 diabetes mellitus. Methods Sixty patients with diabetic peripheral vascular disease treated in the Diabetes Specialist Outpatient and Ward of Guangdong Hospital of Traditional Chinese Medicine from June 2016 to June 2017 were selected as the research objects. According to a randomized, double-blind and controlled study protocol and the random number table method, they were divided into two groups. 30 cases in the treatment group were treated with basic treatment plus Tangbi Washout Formula for footbath, and 30 cases in the control group were treated with routine treatment plus placebo Chinese medicine for footbath. Among which, the basic treatment included regular hypoglycemic, antihypertensive, lipid-lowering and diet exercise therapy. All patients were followed up for 12 weeks. The TCM symptom score, quality of life scale and the levels of interleukin-6 (IL-6) and serum high-sensitivity C-reactive protein (hs-CRP) in the two groups were observed and compared before and after treatment. The experimental data was analyzed by SPSS 19.0. Results After treatment, the scores of TCM syndrome in two groups were lower than those before treatment (P ＜ 0.05), and the scores of quality of life were higher than those before treatment (P ＜ 0.05). After treatment, the score of TCM syndrome in the treatment group was lower than that of the control group (P ＜ 0.05), and the score of quality of life of the treatment group was higher than that of the control group (P ＜ 0.05). The total effective rate of the treatment group was significantly higher than that of the control group (P ＜ 0.05). After treatment, the levels of hs-CRP and IL-6 in the treatment group were lower than those before treatment, which were also lower than those of control group, the differences were statistically significant (P ＜ 0.05). Conclusion Tangbi Washout Formula can effectively improve the clinical symptoms of numbness, pain, paresthesia, intermittent claudication and the quality of life in patients with diabetic peripheral vascular disease, and decrease the levels of inflammatory factors IL-6 and hs-CRP.
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