右美托咪定用于小儿麻醉对血流动力学及对苏醒期躁动和术后疼痛的影响

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Abstract Objective To observe the effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children under anesthesia. Methods A total of 60 children with tonsillectomy and adenoidectomy in Renmin Hospital of Wuhan Universiy from March 2016 to March 2017 were selected and randomly divided into Dexmedetomidine group and control group, with 30 cases in each group. Children in the Dexmedetomidine group were given the Dexmedetomidine combined with Sevoflurane for maintenance of anesthesia, and children in the control group were given the Sevoflurane only for anesthesia maintenance. The operation time, anesthesia time, extubation time and recovery time, Heart rate (HR) and mean arterial pressure (MAP) were compared between the two groups in the times that before anesthesia (T0), tracheal intubation (T1), beginning of surgery (T2), end of surgery (T3). The incidence of emergence agitation, the PAED score and FPS score were investigated in the two groups. Results There were no statistically significant difference in operation time, anesthesia time, extubation time and recovery time between the two groups (P > 0.05). HR and MAP were higher at the time T1, T2 and T3 than those at T0 in both groups and there was no statistically significant difference in HR and MAP at T0 between the two groups (P > 0.05). Compared with the control group, HR and MAP at T1 and HR at T3 in the Dexmedetomidine group were lower than those in the control group, the differences were statistically significant (P < 0.05). The incidence of emergence agitation in the Dexmedetomidine group was lower than the control group, the PAED score and FPS score were lower in the Dexmedetomidine group than those in the control group, the differences were statistically significant (P < 0.05). Conclusion Dexmedetomidine can improve the hemodynamics, reduce emergence agitation and relieve postoperative pain in children, which increases the safety and comfort of anesthesia.

Key words： Dexmedetomidine Anesthesia Children Hemodynamics Emergence agitation Postoperative pain

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	YUAN Zhenwu1
	2 YANG Mingchang2 WANG Long1▲

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YUAN Zhenwu1,2 YANG Mingchang2 WANG Long1▲. The Effects of Dexmedetomidine on hemodynamics, emergence agitation and postoperative pain in children[J]. 中国医药导报, 2018, 15(7): 94-97,106.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I7/94

[1] Plambech MZ，Afshari A. Dexmedetomidine in the pediatric population： a review [J]. Minerva Anestesiol，2015， 81（3）：320-332.
[2] Desai PM，Umbarkar SR，Sarkar MS，et al. Conscious sedation using dexmedetomidine for percutaneous transcatheter closure of atrial septal defects：A single center experience [J]. Annals of Cardiac Anaesthesia，2016，19（3）：463.
[3] Amorim MA，Govêia CS，Magalh?es E，et al. Effectofdexmedetomidineinchildrenundergoing general anesthesia with Sevoflurane：a meta-analysis [J]. Braz J Anesthesiol，2017，67（2）：193-198.
[4] 彭旭桦，姜闽英.右美托咪定在小儿围术期的应用进展[J].中国当代医药，2016，23（31）：14-17.
[5] 张欣，李月阳，张永凯，等.右美托咪定在儿科临床镇静的应用现状[J].中国医院药学杂志，2017，37（9）：874-877.
[6] Strom S. Preoperative evaluation，premedication，and induction of anesthesia in infants and children [J]. Curr Opin Anaesthesiol，2012，25（3）：321-325.
[7] Kanaya A. Emergence agitation in children： risk factors，prevention，and treatment [J]. J Anesth，2016，30（2）：261-267.
[8] Dahmani S，Delivet H，Hilly J. Emergence delirium in children： an update [J]. Curr Opin Anaesthesiol，2014，27（3）：309-315.
[9] Blankespoor RJ，Janssen NJ，Wolters AM，et al. Post-hoc revision of the pediatric anesthesia emergence delirium rating scale：clinical improvement of a bedside-tool? [J]. Minerva Anestesiol，2012，78（8）：896-900.
[10] Keating GM. Dexmedetomidine：A Review of Its Use for Sedation in the Intensive Care Setting [J]. Drugs，2015， 75（10）：1119-1130.
[11] Sun L，Guo R，Sun L. Dexmedetomidine for preventing sevoflurane related emergence agitation in children：a meta-analysis of randomized controlled trials [J]. Acta Anaesthesiol Scand，2014，58（6）：642-650.
[12] Makkar JK，Jain D，Jain K，et al. Dexmedetomidine and emergence agitation [J]. Anaesthesia，2015，70（7）：883-884.
[13] Yao Y，Qian B，Lin Y，et al. Intranasal dexmedetomidine premedication reduces minimum alveolar concentration of sevoflurane for laryngeal mask airway insertion and emergence delirium in children： a prospective，randomized，double-blind，placebo-controlled trial [J]. Paediatr Anaesth，2015，25（5）：492-498.
[14] 乔海峰，陈宏志.右美托咪定预防七氟醚麻醉下麦粒肿手术小儿苏醒期躁动的研究[J].中国医科大学学报，2016， 45（9）：843-847.
[15] Afonso J，Reis F. Dexmedetomidine：current role in anesthesia and intensive care [J]. Rev Bras Anestesiol，2012，62（1）：118-133.
[16] Constantin JM，Momon A，Mantz J，et al. Efficacy and safety of sedation with dexmedetomidine in critical care patients：a meta-analysis of randomized controlled trials [J]. Anaesthesia Critical Care & Pain Medicine，2015，35（1）：7-15.
[17] 柳磊，杜博英，李滨，等.右美托咪定对婴幼儿心脏手术后免疫功能和炎性因子的影响[J].河北医药，2017，39（7）：1014-1016.
[18] Weerink MAS，Struys MMRF，Hannivoort LN，et al. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine [J]. Clin Pharmacokinet，2017，56（8）：893-913.
[19] Bellon M，Bot AL，Michelet D，et al. Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management：A Meta-Analysis of Published Studies [J]. Pain & Therapy，2016，5（1）：63-80.
[20] Nasr DA，Abdelhamid HM. The efficacy of caudal dexmedetomidine on stress response and postoperative pain in pediatric cardiac surgery [J]. Ann Card Anaesth，2013， 16（2）：109-114.