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| Recent research progress on the pharmacological mechanisms of anti-aging and anti-oxidation by salidroside |
| LI Hui SUN Ledong |
| Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangdong Province, Guangzhou 510282, China |
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Abstract Rhodiola is a rare wild medicinal material.Salidroside is the main effective component of Rhodiola and has significant anti-aging and anti-oxidant pharmacological effects. After reviewing and summarizing the recent 3-year relative research at home and abroad, we found that studies mainly involved nervous system, cardiovascular system, skin and other aspects. The specific pharmacological mechanisms involved PI3K/Akt/GSK-3β,PI3K/Akt/Nrf2/HO-1, SIRT1/NF-κB, cAMP/PKA/CREB, NOX2/ROS/MAPKs, autophagy and so on. In conclusion, this review is of great significance for researchers who try to further research pharmacological mechanisms of salidroside and take use of targeted pathways to develop new drugs.
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