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| Progress in the study of Bcl-2 and tumor metastasis |
| LIU Lei1 LI Yan2 WANG Shasha3 |
1.Research Center of Experimental Medicine, the Third People's Hospital of Chengdu Second Affiliated Hospital, Chongqing Medical University, Sichuan Province, Chengdu 610031, China;
2.Department of Infectious Diseases, No.42 Hospital of PLA, Sichuan Province, Leshan 614000, China; 3.Department of Biotechnology, Chengdu Medical College, Sichuan Province, Chengdu 610083, China |
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Abstract Metastasis is one of the most important biological characteristics of malignant tumor, and it is the main risk factor to the patient's life. Bcl-2 is considered as a key factor in anti-apoptosis, but recent studies show that Bcl-2 may play an important role in promoting tumor metastasis. In this paper, review the function of bcl-2 in regulating cell migration, invasion and tumor metastasis and discuss associated molecular mechanism in cellular, animal models and patients levels, and also make a prospect for the therapeutic strategy to target Bcl-2, in order to provide a basis for the inhibition of tumor metastasis.
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