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| The effect of Qiliqiangxin Capsules on cardiac function and prognosis of patients with ST-segment elevation acute myocardial infarction after PCI |
| LI Ying ZHAO Lihong |
| Integrated TCM & Western Medicine Department, the Second Policlinic Directly under the Authority of Hebei Province, Hebei Province, Shijiazhuang 050000, China |
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Abstract Objective To study the effect of Qiliqiangxin Capsules on cardiac function and prognosis of patients with ST-segment elevation acute myocardial infarction after percutaneous coronary intervention (PCI). Methods From January 2016 to May 2017, 60 patients with ST-segment elevation acute myocardial infarction after PCI in the Second Policlinic Directly under the Authority of Hebei Province were selected and divided into observation group and control group according to treatment, with 30 cases in each group. All patients were treated with conventional western medicine treatment after PCI. In addition to standard therapy, the observation group was treated by Qiliqiangxin Capsules, and the control group were treated by placebo. Before and 6 months after treatment, the matrix metalloproteinase-9 (MMP-9), tumor necrosis factor alpha (TNF-α) and nitric oxide (NO) concentration were compared. And the left ventricular ejection fraction (LVEF), left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWD), interventricular septal thickness (IVSd), and cardiac events were also compared. Results After treatment, the levels of MMP-9, TNF-α in the observation group were lower than those in the control group, and the leud of NO was higher than that in the control group, with statistically significant difference (P < 0.05). After treatment, the level of LVEF in the observation group was higher than that in the control group, and the levels of LVEDD, LVPWD, IVSd in the observation group were lower than those in the control group, with statistically significant difference (P < 0.05). The incidence of cardiac events in the control group was lower than that in the control group (P < 0.05). Conclusion Qiliqiangxin Capsules is beneficial to the repair of damaged myocardial cells. Besides, it can improve the ability of myocardium contraction, promote myocardial microcirculation andinhibit ventricular remodeling after myocardial infarction.
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